Process intensification using modified branched chain amino acids

WEBINAR

Increasing demands for biotherapeutics require innovative solutions for process intensification. Highly concentrated cell culture media development is limited by low solubility of leucine and isoleucine. Highly soluble, bioavailable N-lactoyl-leucine and N-lactoyl-isoleucine sodium salts were developed for fed-batch and perfusion processes. They enabled the development of concentrated media applied to in-line dilution processes. Modified amino acids demonstrated comparable performance to canonical amino acids regarding cell growth, productivity, and product quality in CHO cells, enabling next-generation bioprocesses with reduced storage requirements and smaller production footprints.

In this webinar, you will learn:

• How to concentrate your media & feeds by replacing low soluble amino acids with their modified version.
• How to intensify your processes in either Fed-batch or Perfusion Applications.
• How modified amino acids are metabolized by Chinese Hamster Overy cells.