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483400 7-Nitroindazole - CAS 2942-42-9 - Calbiochem

A cell-permeable, reversible and competitive inhibitor of nitric oxide synthase (NOS) with high selectivity for the brain enzyme (IC₅₀ = 710 nM) vs.

7-Nitroindazole - CAS 2942-42-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7-Ni

Primary Target: NOS
483400
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      2942-42-9C₇H₅N₃O₂
      Description
      Overview

      This product has been discontinued.



      A cell-permeable, reversible and competitive inhibitor of nitric oxide synthase (NOS) with high selectivity for the brain enzyme (IC50 = 710 nM) vs. iNOS (IC50 = 20 µM). Also inhibits bovine endothelial nitric oxide synthase (IC50 = 800 nM). Binds to the heme group of NOS.
      Catalogue Number483400
      Brand Family Calbiochem®
      Synonyms7-Ni
      References
      ReferencesSchulz, J.B., et al. 1995. J. Neurochem. 64, 936.
      Klatt, P., et al. 1994. J. Biol. Chem. 269, 13861.
      Wolff, D.J., et al. 1994. Arch. Biochem. Biophys. 314, 360.
      Babbedge, R.C., et al. 1993. Br. J. Pharmacol. 110, 225.
      Moore, P.K., et al. 1993. Br. J. Pharmacol. 108, 296.
      Product Information
      CAS number2942-42-9
      ATP CompetitiveY
      FormYellowish brown solid
      Hill FormulaC₇H₅N₃O₂
      Chemical formulaC₇H₅N₃O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetNOS
      Primary Target IC<sub>50</sub>710 nM against the brain enzyme nitric oxide synthase (NOS)
      Purity≥97% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSNK7962200
      Safety Information
      R PhraseR: 40-60

      Limited evidence of a carcinogenic effect.
      May impair fertility.
      S PhraseS: 53-22-36/37/39-45

      Avoid exposure - obtain special instructions before use.
      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.


      From Catalog:
      Desc. Field- added "cell-permeable
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      483400 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      7-Nitroindazole - CAS 2942-42-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      7-Nitroindazole - CAS 2942-42-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      483400

      References

      Reference overview
      Schulz, J.B., et al. 1995. J. Neurochem. 64, 936.
      Klatt, P., et al. 1994. J. Biol. Chem. 269, 13861.
      Wolff, D.J., et al. 1994. Arch. Biochem. Biophys. 314, 360.
      Babbedge, R.C., et al. 1993. Br. J. Pharmacol. 110, 225.
      Moore, P.K., et al. 1993. Br. J. Pharmacol. 108, 296.

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-August-2008 RFH
      Synonyms7-Ni
      DescriptionA reversible and competitive inhibitor of nitric oxide synthase (NOS) with high selectivity for the brain enzyme (IC50 = 710 nM). Also inhibits bovine endothelial nitric oxide synthase (IC50 = 800 nM). Binds to the heme group of NOS.
      FormYellowish brown solid
      CAS number2942-42-9
      RTECSNK7962200
      Chemical formulaC₇H₅N₃O₂
      Structure formulaStructure formula
      Purity≥97% by TLC
      SolubilityDMSO (50 mg/ml) or Methanol (5 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.


      From Catalog:
      Desc. Field- added "cell-permeable
      Toxicity Carcinogenic / Teratogenic
      ReferencesSchulz, J.B., et al. 1995. J. Neurochem. 64, 936.
      Klatt, P., et al. 1994. J. Biol. Chem. 269, 13861.
      Wolff, D.J., et al. 1994. Arch. Biochem. Biophys. 314, 360.
      Babbedge, R.C., et al. 1993. Br. J. Pharmacol. 110, 225.
      Moore, P.K., et al. 1993. Br. J. Pharmacol. 108, 296.