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F9427

Fexofenadine hydrochloride

Name: Fexofenadine hydrochloride
Brand: SIGMA

>98% (HPLC), H1 histamine receptor antagonist, powder

Synonym(s):

Fexofenidine hydrochloride, MDL 16455 hydrochloride, Terfenidine carboxylate hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₃₂H₃₉NO₄ · HCl

CAS Number:

153439-40-8

Molecular Weight:

538.12

UNSPSC Code:

12352200

PubChem Substance ID:

24278447

NACRES:

NA.77

MDL number:

MFCD00865710

Assay:

>98% (HPLC)

Form:

powder

Storage condition:

desiccated

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Properties

Product Name

Fexofenadine hydrochloride, >98% (HPLC)

Quality Segment

100

assay

>98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: soluble ≥5 mg/mL

originator

Sanofi Aventis

storage temp.

−20°C

SMILES string

Cl[H].CC(C)(C(O)=O)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4

InChI

1S/C32H39NO4.ClH/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27;/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36);1H

InChI key

RRJFVPUCXDGFJB-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

Description

Application

Fexofenadine hydrochloride has been used as a non-cationic ampliphilic antihistamines in NCI-H661 cells and as a histamine H1 receptor antagonist in mice

Biochem/physiol Actions

Fexofenadine is used in treating allergic rhinitis and chronic idiopathic urticaria. It may give relief in bothersome symptom and is a second-generation antihistamines. Fexofenadine provides better relief compared to other antihistamines for nasal congestion. It is the active metabolite of terfenadine and bring down allergen-induced symptoms.

Fexofenadine is a non-sedating H1 histamine receptor antagonist.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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