H0165
7-Ethyl-10-hydroxycamptothecin
powder, ≥98% (HPLC)
Synonym(s):
SN-38
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About This Item
Empirical Formula (Hill Notation):
C22H20N2O5
CAS Number:
Molecular Weight:
392.40
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
7-Ethyl-10-hydroxycamptothecin, ≥98% (HPLC), powder
biological source
Artemisia annua
Quality Segment
assay
≥98% (HPLC)
form
powder
solubility
DMSO: 1 mg/mL
storage temp.
−20°C
SMILES string
OC1=CC2=C(CC)C(C3)=C(N=C2C=C1)C(N3C4=O)=CC5=C4COC([C@]5(O)CC)=O
InChI
1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
InChI key
FJHBVJOVLFPMQE-QFIPXVFZSA-N
Application
7-Ethyl-10-hydroxycamptothecin has been used:
- to inhibit enterovirus 71 (EV71) (H) infection
- to screen the chemosensitivity of pancreatic adenocarcinoma cells
- as a chemical to study its ability to reverse multidrug resistance (MDR), due to ATP binding cassette (ABC) transporters
Biochem/physiol Actions
Active metabolite of irinotecan. Inhibitor of topoisomerase I.
Active metabolite of irinotecan. Inhibitor of topoisomerase I.. Gene expression analysis of colon cancer cell lines treated with SN-38 showed differential effects: the majority of affected genes were down-regulated (including, most strongly, genes related to receptor and kinase activity, signal transduction, apoptosis, RNA processing, protein metabolism and transport, cell cycle and transcription. Some of the up-regulated genes were involved in apoptosis, transcription, development and differentiation.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 1B - STOT RE 1
target_organs
Gastro-intestinal system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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