Parteck® Functional Excipients
When you design a solid dosage formulation, there are many factors to consider: the active pharmaceutical ingredient (API), bioavailability enhancement, release kinetics, specific dosage, packaging, shelf life, and more. Excipients are the backbone of a formulation and affect final formulation properties such as processability, stability and performance. Therefore, it is important to consider an excipient that has the correct functionality and is of high quality.
Our Parteck® functional excipients were designed with these formulator’s challenges in mind and have additional functionalities beyond standard excipients. These excipients are particle optimized and feature unique particle properties tailored for tableting processes, for specific drug delivery technologies, or for solubility enhancement. Thus, our Parteck® functional excipients ensure excellent performance in formulation development and manufacturing. Backed by the Emprove® Program with its stringent quality control, as well as regulatory support and documentation, Parteck® excipients help to speed up your approval processes.
Products
Flexible Tableting
- High tablet hardness at low compression forces, providing tablet robustness and rapid disintegration
- High and low API dosages enabled by the unique particle surface
- Specialized excipients for direct compression, wet and dry granulation, film coating, lubrication, and rapid disintegration
Optimized Drug Delivery
- Options for modifying release kinetics, such as orally disintegrating tablets and sustained-release solid oral formulations
- Specialized excipients for different routes of administration, including dry powder inhalation
Enhanced Solubility
- Specialized excipients for hot melt extrusion, dissolution rate enhancement in tableting and a silica drug carrier with a unique surface structure
- Enhanced API solubility to boost the efficacy of your final drug product
Related Product Resources
- Article: Tablet Manufacturing Technologies for Solid Drug Formulation
Learn about common tablet manufacturing technologies and the advantages and disadvantages of each.
- Article: Active Pharmaceutical Ingredient (API) Stability in Solid Dose Formulation
This article describes the use of excipients to help address API stability issues.
- Article: API Solubility and Dissolution Enhancement Via Formulation
Our overview of API solubility and dissolution enhancement methods can help you decide between the many options to take during formulation.
- Article: Dry Granulation in Solid Oral Formulation: Advantages of Spray-Dried Mannitol in Roll Compaction
In recent years, mannitol has gained popularity as an excipient in solid dosage formulation due to its beneficial physicochemical properties.
- Article: Solid Formulation Development Using Melt-based 3D Printing Technologies
3D printing can overcome challenges during formulation development, with a focus on enhancing API bioavailability in solid dispersions. Find out how in this technical article.
- Article: Use of Mannitol as an Excipient for Solid Drug Formulation
This article describes the advantages of mannitol when used as an excipient in solid drug formulation.
- Article: Improving API Solubility Using Hot Melt Extrusion Formulation With Polyvinyl Alcohol
Find out how Hot Melt Extrusion with polyvinyl alcohol (PVA) is used to enhance API solubility.
- Download: Formulation Handbook
Formulating pharmaceutical dosage forms: In this formulation handbook, we have compiled information and formulation examples that can help you when developing your formulation.
- White Paper: API Stability in Solid Dose Formulation – Exploring the Myth of Inert Excipients
Stable active pharmaceutical ingredients (APIs) are critical for drug formulation due to their impact on patient safety, regulatory acceptance, drug shelf-life, wastage, and storage requirements. API instability can lead to reduced drug dosage, formation of toxic degradation products, and increased costs for storage, potentially harming patient safety and economic viability.
- White Paper: New Opportunities for Oral Sustained Release Formulations with Polyvinyl Alcohol
Achieving appropriate release kinetics for an active pharmaceutical ingredient (API) is crucial for therapeutic success. Consistent API dosing in sustained release formulations ensures that blood plasma levels remain within the therapeutic window, maintaining efficacy while avoiding toxic side effects.
- White Paper: Considerations for Dosing Accuracy in a New Carrier for Dry Powder Inhalation
Inhalation drug delivery offers rapid action and good bioavailability, but precise dosing is difficult due to small dosage amounts and diverse forms of APIs.
- White Paper: The Developability Classification System (DCS): Enabling an Optimized Approach for Formulation of Poorly Soluble Molecules
Adequate solubility in gastrointestinal fluids is essential for the effectiveness of orally administered solid dosage forms. Most absorption occurs in the small intestine, where the drug needs to dissolve sufficiently to enter the systemic circulation. If the drug is not soluble in these fluids, it cannot produce the intended physiological effect.
