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287893 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole 3ʹ,5ʹ-cyclic Monophosphorothioate, Sp-Isomer, Sodium Salt

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole 3ʹ,5ʹ-cyclic Monophosphorothioate, Sp-Isomer, Sodium Salt MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Sp-5,6-DCl-cBIMPS, Na

287893
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      120912-54-1C₁₂H₁₀Cl₂N₂O₅PS · Na
      Description
      Overview

      This product has been discontinued.





      A potent, cell-permeable, specific and site-selective activator of PKA. Displays greater preference for site B of the type II PKA isozyme (Ka = 250 nM). Displays high stability against mammalian phosphodiesterases (PDE) I and III and is only extremely slowly hydrolyzed by PDE type II. Superior to Dibutyryl cAMP (Cat. No. 28745) and 8-CPT-cAMP (Cat. No. 116812) in terms of metabolic stability, cell-permeability, and potency. Note: 5 µmol = 2.1 mg.
      Catalogue Number287893
      Brand Family Calbiochem®
      SynonymsSp-5,6-DCl-cBIMPS, Na
      References
      ReferencesCantrell, A.R., et al. 1999. J. Neurosci. 19, RC21.
      Klages, B., et al. 1999. J. Cell Biol. 144, 745.
      Smolenski, A., et al. 1998. J. Biol. Chem. 273, 20029.
      Cantrell, A.R., et al. 1997. J. Neurosci. 17, 7330.
      Johnson, B.D., et al. 1997. J. Neurosci. 17, 1243.
      Genieser, H.G., et al. 1992. Carbohydr. Res. 234, 217.
      Sandberg, M., et al. 1991. Biochem. J. 279, 521.
      Product Information
      CAS number120912-54-1
      DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
      FormLyophilized
      Hill FormulaC₁₂H₁₀Cl₂N₂O₅PS · Na
      Chemical formulaC₁₂H₁₀Cl₂N₂O₅PS · Na
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      287893 0

      Documentation

      5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole 3ʹ,5ʹ-cyclic Monophosphorothioate, Sp-Isomer, Sodium Salt Certificates of Analysis

      TitleLot Number
      287893

      References

      Reference overview
      Cantrell, A.R., et al. 1999. J. Neurosci. 19, RC21.
      Klages, B., et al. 1999. J. Cell Biol. 144, 745.
      Smolenski, A., et al. 1998. J. Biol. Chem. 273, 20029.
      Cantrell, A.R., et al. 1997. J. Neurosci. 17, 7330.
      Johnson, B.D., et al. 1997. J. Neurosci. 17, 1243.
      Genieser, H.G., et al. 1992. Carbohydr. Res. 234, 217.
      Sandberg, M., et al. 1991. Biochem. J. 279, 521.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-June-2008 RFH
      SynonymsSp-5,6-DCl-cBIMPS, Na
      DescriptionA potent, cell-permeable, specific and site-selective activator of PKA. Displays greater preference for site B of the type II PKA isozyme (Ka = 250 nM). Exhibits resistance against mammalian phosphodiesterases (PDE) types I and III and is only extremely slowly hydrolyzed by PDE type II. Superior to Dibutyryl-cAMP (Cat. No. 287745) and 8-CPT-cAMP (Cat. No. 116812) in terms of its metabolic stability, cell-permeability, and potency.
      FormLyophilized
      CAS number120912-54-1
      Chemical formulaC₁₂H₁₀Cl₂N₂O₅PS · Na
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml), Ethanol or H₂O
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCantrell, A.R., et al. 1999. J. Neurosci. 19, RC21.
      Klages, B., et al. 1999. J. Cell Biol. 144, 745.
      Smolenski, A., et al. 1998. J. Biol. Chem. 273, 20029.
      Cantrell, A.R., et al. 1997. J. Neurosci. 17, 7330.
      Johnson, B.D., et al. 1997. J. Neurosci. 17, 1243.
      Genieser, H.G., et al. 1992. Carbohydr. Res. 234, 217.
      Sandberg, M., et al. 1991. Biochem. J. 279, 521.