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658410 AG 183

AG 183 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Amino-4-(3ʹ,4ʹ,5ʹ-trihydroxyphenyl)-1,1,3-tricyanobuta-1,3-diene, Tyrphostin A51

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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      We apologize for the inconvenience, but we do not currently have an alternative product.

      Please refer to our complete listing of protein tyrosine kinase inhibitors for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.





      A cell-permeable, reversible, substrate competitive inhibitor of epidermal growth factor receptor tyrosine kinase (IC50 = 800 nM).
      Catalogue Number658410
      Brand Family Calbiochem®
      Synonyms2-Amino-4-(3ʹ,4ʹ,5ʹ-trihydroxyphenyl)-1,1,3-tricyanobuta-1,3-diene, Tyrphostin A51
      References
      ReferencesLevitzki, A. 1990. Biochem. Pharmacol. 40, 913. Gazit, A., et al. 1989. J. Med. Chem. 32, 2344. Posner, I., et al. 1989. FEBS Lett. 256, 287. Yaish, P., et al. 1988. Science 242, 933.
      Product Information
      CAS number126433-07-6
      FormOrange solid
      Hill FormulaC₁₃H₈N₄O₃
      Chemical formulaC₁₃H₈N₄O₃
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Targetepidermal growth factor receptor tyrosine kinase
      Primary Target IC<sub>50</sub>800 nM
      Purity≥98% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      658410 0

      Documentation

      AG 183 Certificates of Analysis

      TitleLot Number
      658410

      References

      Reference overview
      Levitzki, A. 1990. Biochem. Pharmacol. 40, 913. Gazit, A., et al. 1989. J. Med. Chem. 32, 2344. Posner, I., et al. 1989. FEBS Lett. 256, 287. Yaish, P., et al. 1988. Science 242, 933.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-January-2010 RFH
      Synonyms2-Amino-4-(3ʹ,4ʹ,5ʹ-trihydroxyphenyl)-1,1,3-tricyanobuta-1,3-diene, Tyrphostin A51
      DescriptionA cell-permeable, reversible, substrate competitive inhibitor of epidermal growth factor receptor tyrosine kinase (IC50 = 800 nM).
      FormOrange solid
      CAS number126433-07-6
      Chemical formulaC₁₃H₈N₄O₃
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO or ethanol (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesLevitzki, A. 1990. Biochem. Pharmacol. 40, 913. Gazit, A., et al. 1989. J. Med. Chem. 32, 2344. Posner, I., et al. 1989. FEBS Lett. 256, 287. Yaish, P., et al. 1988. Science 242, 933.