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MAB3804 Anti-53BP1 Antibody, clone BP18

Anti-53BP1 Antibody, clone BP18 is a Mouse Monoclonal Antibody for detection of 53BP1 also known as p53 Binding Protein 1 & has been validated in IF & WB.

Anti-53BP1 Antibody, clone BP18 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Cell Cycle, DNA Replication & Repair Gene Symbol: TP53BP1, 53BP1, MGC138366, p202, p53BP1, FLJ41424 UniProt Number: Q12888
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MAB3804
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, HIF, WBMAscitesMonoclonal Antibody
      Description
      Catalogue NumberMAB3804
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-53BP1 Antibody, clone BP18
      Alternate Names
      • p53 Binding Protein 1
      References
      Product Information
      FormatAscites
      PresentationAscites. Liquid.
      Quality SegmentMQ100
      Applications
      ApplicationAnti-53BP1 Antibody, clone BP18 is a Mouse Monoclonal Antibody for detection of 53BP1 also known as p53 Binding Protein 1 & has been validated in IF & WB.
      Key Applications
      • Immunofluorescence
      • Western Blotting
      Application NotesWestern blot. Recognizes a protein of >250 kD. Suggested dilution buffer is TBST. Suggested blocking buffer is 5% non-fat dry milk.

      Immunocytochemistry

      Immunoprecipitation. Expected size in immunoblot is >250 kD. Suggested lysis buffer is NETN. Suggested capture agent is Protein A + rabbit anti-mouse linker antibody.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenRecombinant human 53BP1 proteins.
      CloneBP18
      HostMouse
      Specificity53BP1
      IsotypeIgM
      Species Reactivity
      • Mouse
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TP53BP1
      • 53BP1
      • MGC138366
      • p202
      • p53BP1
      • FLJ41424
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q12888 # May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Binds to sites of DNA damage. Plays a role in the response to DNA damage.
      SIZE: 1972 amino acids; 213574 Da
      SUBUNIT: Interacts with IFI202A (By similarity). Binds to the central domain of TP53/p53. May form homo-oligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on 'Ser-139'. Interacts with histone H3 that has been methylated on 'Lys-79'. Does not bind unmethylated histone H3.
      SUBCELLULAR LOCATION: Nucleus. Kinetochore. Note=Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks.
      PTM: Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding. & Phosphorylated in an ATM-dependent manner in response to DNA damage.
      SIMILARITY: SwissProt: Q12888 ## Contains 2 BRCT domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      MAB3804 04053252466168

      Documentation

      Anti-53BP1 Antibody, clone BP18 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-53BP1 Antibody, clone BP18 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-53BP1 MONOCLONAL ANTIBODY - 2388959 2388959
      MOUSE ANTI-53BP1 - 3202259 3202259
      MOUSE ANTI-53BP1 - 3407306 3407306
      MOUSE ANTI-53BP1 - 3587223 3587223
      MOUSE ANTI-53BP1 - 3792957 3792957
      MOUSE ANTI-53BP1 - 4041933 4041933
      MOUSE ANTI-53BP1 -2796318 2796318
      MOUSE ANTI-53BP1 -2844572 2844572
      MOUSE ANTI-53BP1 MONOCLONAL ANTIBODY 2938838
      MOUSE ANTI-53BP1 MONOCLONAL ANTIBODY - 1999450 1999450
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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies