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236002 Anti-COX2, C-Terminal Rabbit pAb

This Anti-COX2, C-Terminal Rabbit pAb is validated for use in Immunoblotting, ELISA for the detection of COX2, C-Terminal.

Anti-COX2, C-Terminal Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-Cyclooxygenase-2, Anti-PGHS-2, Anti-Prostaglandin H Synthase-2

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236002
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Overview

Replacement Information

Key Spec Table

Species ReactivityHostAntibody Type
B, H, M, R, ShRbPolyclonal Antibody

Pricing & Availability

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236002-50UG
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      Description
      OverviewRecognizes COX2. Does not cross-react with COX1.
      Catalogue Number236002
      Brand Family Calbiochem®
      SynonymsAnti-Cyclooxygenase-2, Anti-PGHS-2, Anti-Prostaglandin H Synthase-2
      References
      ReferencesHla, T., and Neilson, K. 1992. Proc. Natl. Acad. Sci. USA 89, 7384.
      Product Information
      FormLiquid
      FormulationIn PBS, 0.1% BSA, pH 7.4.
      Preservative≤0.1% sodium azide
      Quality SegmentMQ100
      Applications
      Key Applications Enzyme-Linked Immunosorbent Assay
      Immunoblotting (Western Blotting)
      Application NotesImmunoblotting (1-10 µg/ml, chemiluminescence)
      ELISA (1:10,000-1:100,000)
      Application CommentsDoes not cross-react with COX1. Variables associated with assay conditions will dictate the optimal working dilution.
      Biological Information
      Immunogena synthetic peptide corresponding to a 17-amino acid sequence near the C-terminus of human COX2
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Bovine
      • Human
      • Mouse
      • Rat
      • Sheep
      Antibody TypePolyclonal Antibody
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      236002-50UG 04055977217094

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Anti-COX2, C-Terminal Rabbit pAb SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-COX2, C-Terminal Rabbit pAb Certificates of Analysis

      TitleLot Number
      236002

      References

      Reference overview
      Hla, T., and Neilson, K. 1992. Proc. Natl. Acad. Sci. USA 89, 7384.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-July-2007 RFH
      SynonymsAnti-Cyclooxygenase-2, Anti-PGHS-2, Anti-Prostaglandin H Synthase-2
      ApplicationImmunoblotting (1-10 µg/ml, chemiluminescence)
      ELISA (1:10,000-1:100,000)
      DescriptionImmunoaffinity purified rabbit polyclonal antibody. Recognizes the ~72 kDa COX2 protein.
      BackgroundCOX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Nonsteroidal anti-inflammatory drugs) such as aspirin. Prostaglandins (PGs) formed by the enzymatic activity of COX1 are primarily involved in the regulation of homeostatic functions throughout the body, whereas PGs formed by COX2 primarily mediate pain, fever, and inflammation. COX2 is induced by a wide variety of stimuli and was initially identified as an immediate-early growth response gene. In addition, COX2 expression is markedly increased in 85-90% of human colorectal adenocarcinomas, whereas COX1 levels remain unchanged. COX2 may be involved in angiogenesis, as new angiogenic endothelial cells express the inducible COX2 while normal blood vessels express COX1.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide corresponding to a 17-amino acid sequence near the C-terminus of human COX2
      IsotypeIgG
      Speciesbovine, human, mouse, rat, sheep
      FormLiquid
      FormulationIn PBS, 0.1% BSA, pH 7.4.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative≤0.1% sodium azide
      CommentsDoes not cross-react with COX1. Variables associated with assay conditions will dictate the optimal working dilution.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesHla, T., and Neilson, K. 1992. Proc. Natl. Acad. Sci. USA 89, 7384.