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AB15570 Anti-Tryptophan hydroxylase 1 Antibody

Detect Tryptophan hydroxylase 1 using this Anti-Tryptophan hydroxylase 1 Antibody validated for use in IH, IP & WB.

Anti-Tryptophan hydroxylase 1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: TPH1, TPRH, MGC119994, TRPH, TPH, EC 1.14.16.4 UniProt Number: P17752
AB15570
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, R, RbIHC, IP, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB15570
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Tryptophan hydroxylase 1 Antibody
      Alternate Names
      • TPH1
      References
      Product Information
      FormatPurified
      PresentationLiquid.
      Applications
      ApplicationDetect Tryptophan hydroxylase 1 using this Anti-Tryptophan hydroxylase 1 Antibody validated for use in IH, IP & WB.
      Key Applications
      • Immunohistochemistry
      • Immunoprecipitation
      • Western Blotting
      Application NotesWestern blot: 1:1,000 (overnight incubation) on rat and mouse pineal gland lysate using ECL.
      Immunohistochemistry: 1:1,500 (overnight incubation) on mouse gut tissue.
      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide from the C-terminal region of TPH1.
      HostRabbit
      SpecificityTryptophan hydroxylase 1 (TPH1). TPH1 is found in the pineal and gut. Recognizes the ~51 kDa TPH1 protein in pineal and P815 mastocytoma cells by Western blot. No reactivity with recombinant TPH2.
      Species Reactivity
      • Mouse
      • Rat
      • Rabbit
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the gut, pineal gland, spleen, and thymus.
      Gene Symbol
      • TPH1
      • TPRH
      • MGC119994
      • TRPH
      • TPH
      • EC 1.14.16.4
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryCOFACTOR: Fe(2+) ion.
      SIZE: 444 amino acids; 50985 Da
      SUBUNIT: Multimer of identical subunits.
      TISSUE SPECIFICITY: Isoform 2 seems to be less widely expressed than isoform 1.
      SIMILARITY: SwissProt: P17752 ## Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. & Contains 1 ACT domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at 4°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      AB15570 04053252509339

      Documentation

      References

      Reference overviewPub Med ID
      Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies
      Sakowski, Stacey A, et al
      Brain Res, 1085:11-8 (2006)  2006

      		16581041 16581041

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies