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AB3889 Anti-Vav-3 Antibody

This Anti-Vav-3 Antibody is validated for use in WB for the detection of Vav-3.

Research Category: Signaling Research Sub-Category: Cytoskeletal Signaling Gene Symbol: VAV3, FLJ40431 UniProt Number: Q9UKW4
AB3889
50 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB3889
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Vav-3 Antibody
      Background InformationVav proteins function as Rho family guanine nucleotide exchange factors (GEFs), binding to the nucleotide-free state of these GTPases. The Rho family of GTPases are a key class of signaling molecules that mediate receptor induced rearrangements of the actin cytoskeleton, activation of kinase cascades and changes in gene transcription. Vav-3 is an exchange factor for RhoA, RhoG and, to a lesser extent, Rac1.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Western blot positive control: HeLa cell line
      PresentationAffinity purified immunoglobulin. Liquid in 0.02M Phosphate Buffer, 0.25M NaCl, with 0.1% sodium azide.
      Applications
      ApplicationThis Anti-Vav-3 Antibody is validated for use in WB for the detection of Vav-3.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:5,000 - 1:10,000

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to amino acid residues 566-591 of human Vav3 (Accession # Q9UKW4).
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes human Vav3. This antibody detects a band of approximately 98 kDa in Western blot analysis of HeLa cell lysate. Lower molecular weight non-specific bands may be eliminated by using the antibody at a higher dilution.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
      Gene Symbol
      • VAV3
      • FLJ40431
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9UKW4 # Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases.
      SIZE: 847 amino acids; 97776 Da
      SUBUNIT: Interacts with the PH domain of APS.
      SIMILARITY: SwissProt: Q9UKW4 ## Contains 1 CH (calponin-homology) domain. & Contains 1 DH (DBL-homology) domain. & Contains 1 PH domain. & Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 SH2 domain. & Contains 2 SH3 domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C for up to 12 months from date of receipt.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      AB3889 04053252584893

      Documentation

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      Catalogue Number Description  
      07-464 Anti-Vav3 Antibody, human Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies