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851004 BOP

BOP Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate Novabiochem®. CAS 56602-33-6, molar mass 442.28 g/mol.

BOP MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 56602-33-6 EC Number: 260-279-1 Molar Mass: 442.28 g/mol Hill Formula: C₁₂H₂₂N₆OP * F₆P
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851004
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Overview

Replacement Information

Key Spec Table

CAS #EC NumberHill FormulaMolar Mass
56602-33-6260-279-1C₁₂H₂₂N₆OP * F₆P442.28 g/mol

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      8510040100
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          Description
          Catalogue Number851004
          Replaces01-62-0001
          Brand Family Novabiochem®
          Alternate Names
          • Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphoniumhexafluorophosphate
          • Castro's Reagent
          Background InformationPeptide coupling reagent which suppresses enantiomerization [1-15]. Reduction of carboxylic acids activated with BOP provides a facile route to alcohols [16].

          Novabiochem® recommends the replacement of BOP by PyBOP®(for PyBOP® please see 851009). The manufacture of BOP, as well as its utilization, involves the use or the formation of hexamethylphosphotriamide, the carcinogenicity and respiratory toxicity of which has been the subject of numerous reports.

          The product number for this product was previously 01-62-0001.

          To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
          References
          Product Information
          CAS number56602-33-6
          EC number260-279-1
          Hill FormulaC₁₂H₂₂N₆OP * F₆P
          Molar Mass442.28 g/mol
          HS Code2933 99 80
          Structure formula ImageStructure formula Image
          Quality SegmentMQ200
          Applications
          ApplicationBOP Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate Novabiochem®. CAS 56602-33-6, molar mass 442.28 g/mol.
          Biological Information
          Physicochemical Information
          Melting Point138 - 145 °C
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Hazard Pictogram(s) Hazard Pictogram(s)
          Hazard Pictogram(s)
          Hazard Statement(s)H228: Flammable solid.
          H315: Causes skin irritation.
          H335: May cause respiratory irritation.
          EUH044: Risk of explosion if heated under confinement.
          Precautionary Statement(s)P210: Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
          P240: Ground and bond container and receiving equipment.
          P241: Use explosion-proof electrical/ ventilating/ lighting equipment.
          P261: Avoid breathing dust.
          P264: Wash skin thoroughly after handling.
          P302 + P352: IF ON SKIN: Wash with plenty of water.
          Signal WordDanger
          Storage class4.1A Other explosive hazardous materials
          WGKWGK 3 highly hazardous to water
          Safety Information
          Categories of dangerirritant
          Product Usage Statements
          Storage and Shipping Information
          StorageStore at +2°C to +8°C.
          Packaging Information
          Transport Information
          Declaration (railroad and road) ADR, RIDUN 1325 , 4.1, II
          Declaration (transport by air) IATA-DGRUN 1325 , 4.1, II
          Declaration (transport by sea) IMDG-CodeUN 1325 , 4.1, II
          Supplemental Information
          Specifications
          Color (visual)white to slight yellow to beige
          Appearance of substance (visual)powder
          Identity (IR)passes test
          Assay (HPLC, area%)≥ 99.0 % (a/a)
          Solubility (0.6 mmole in 1 ml DMF)clearly soluble
          Global Trade ITEM Number
          Catalogue Number GTIN
          8510040025 04027269080846
          8510040100 04027269080853

          Documentation

          BOP SDS

          Title

          Safety Data Sheet (SDS) 

          Citations

          Title
          • [1] B. Castro, et al. (1975) Tetrahedron Lett., 16, 1219.
          • [2] B. Castro, et al. (1976) Synthesis, 751.
          • [3] B. Castro, et al. (1977) Synthesis, 413.
          • [4] B. Castro, et al. (1977) J. Chem. Res. (S), 182.
          • [5] P. Rivaille, et al. (1980) Tetrahedron, 36, 3413.
          • [6] D. L. Nguyen, et al. (1985) J. Chem. Soc., Perkin Trans. 1, 1025.
          • [7] D. L. Nguyen, et al. (1987) J. Chem. Soc., Perkin Trans. 1, 1915.
          • [8] A. Fournier, et al. (1988) Int. J. Peptide Protein Res., 31, 86 and 231.
          • [9] J.-P. Briand, et al. (1989) Pept. Res., 2, 381.
          • [10] A. Fournier, et al. (1989) Int. J. Peptide Protein Res., 33, 133.
          • [11] D. L. Nguyen, et al. (1989) Biochem. Biophys. Res. Commun., 162, 1425.
          • [12] W. K. Rule, et al. in 'Peptides 1988, Proc. 20th European Peptide Symposium', G. Jung & E. Bayer (Eds), Walter de Gruyter, Berlin, 1989, pp. 238.
          • [13] M. Forest, et al. (1990) Int. J. Peptide Protein Res., 35, 89.
          • [14] R. Seyer, et al. (1990) Int. J. Peptide Protein Res., 35, 465.
          • [15] H. Gausepohl, et al. in 'Innovation & Perspectives in Solid Phase Synthesis, 2nd International Symposium', R. Epton (Eds), Intercept UK Ltd., Andover, 1993, pp. 387.
          • [16] R. P. McGeary (1998) Tetrahedron Lett., 39, 3319.