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197332 Bcl-2 Inhibitor III, EM20-25 - CAS 141266-44-6 - Calbiochem

Bcl-2 Inhibitor III, EM20-25 - CAS 141266-44-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-(6-Chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diaza-anthracen-10-yl)-pyrimidine-2,4,6-trione

Primary Target: Bcl-2
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      141266-44-6C₁₅H₉ClN₄O₆
      Description
      Overview

      This product has been discontinued.



      A cell-permeable pyrimidine-trione compound that sensitizes apoptosis-resistant, Bcl-2-overexpressing leukemic cells to cytotoxic drugs. Shown to bind to Bcl-2, disrupt its interaction with Bax, and activate caspase-9. Also induces PTP (permeability transition pore) opening in both isolated mitochondria and intact cells, without any effect on respiration.
      Catalogue Number197332
      Brand Family Calbiochem®
      Synonyms5-(6-Chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diaza-anthracen-10-yl)-pyrimidine-2,4,6-trione
      References
      ReferencesMilanesi, E., et al. 2006. J. Biol. Chem. 281, 10066.
      Product Information
      CAS number141266-44-6
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₁₅H₉ClN₄O₆
      Chemical formulaC₁₅H₉ClN₄O₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality SegmentMQ100
      Applications
      Biological Information
      Primary TargetBcl-2
      Purity≥95% by elemental analysis
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      197332 0

      Documentation

      Bcl-2 Inhibitor III, EM20-25 - CAS 141266-44-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Bcl-2 Inhibitor III, EM20-25 - CAS 141266-44-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      197332

      References

      Reference overview
      Milanesi, E., et al. 2006. J. Biol. Chem. 281, 10066.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonyms5-(6-Chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diaza-anthracen-10-yl)-pyrimidine-2,4,6-trione
      DescriptionA cell-permeable pyrimidine-trione compound that sensitizes apoptosis-resistant, Bcl-2-overexpressing leukemic cells to cytotoxic drugs. Shown to bind to Bcl-2, disrupt its interaction with Bax, and activate caspase-9. Also induces PTP (permeability transition pore) opening in both isolated mitochondria and intact cells, without any effect on respiration.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number141266-44-6
      Chemical formulaC₁₅H₉ClN₄O₆
      Structure formulaStructure formula
      Purity≥95% by elemental analysis
      SolubilityDMSO (2 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      ReferencesMilanesi, E., et al. 2006. J. Biol. Chem. 281, 10066.