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505895 CGP 35348 - CAS 123690-79-9 - Calbiochem

CGP 35348 - CAS 123690-79-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: GABAB Receptor Antagonist, CGP 35348, CGP35348, CGP-35348

Primary Target: GABAB
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
123690-79-9C₈H₂₀NO₄P
Description
Overview

This product has been discontinued.



A selective antagonist of post-synaptic GABAB receptors (IC50 = 34 µM) that can permeate the blood brain barrier. Exhibits about 10-fold lower affinity for pre-synaptic receptors. Blocks K+-evoked glycine exocytosis in mouse spinal cord and hippocampal nerve endings. Shown to antagonize the potentiating effect of L-baclofen on noradrenaline-induced stimulation of adenylate cyclase in rat cortex slices.
Catalogue Number505895
Brand Family Calbiochem®
SynonymsGABAB Receptor Antagonist, CGP 35348, CGP35348, CGP-35348
References
ReferencesRomei, C., et al., 2010. Pharmacol. Res. 61, 547.
Staubli, U., et al., 1999. J. Neurosci. 19, 4609l.
Olpe, H.R., et al. 1990. Eur. J. Pharmacol. 187, 27.
Product Information
CAS number123690-79-9
FormWhite solid
Hill FormulaC₈H₂₀NO₄P
Chemical formulaC₈H₂₀NO₄P
Structure formula ImageStructure formula Image
Quality SegmentMQ100
Applications
Biological Information
Primary TargetGABAB
Primary Target IC<sub>50</sub>34 µ
Purity≥98% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade ITEM Number
Catalogue Number GTIN
505895 0

Documentation

CGP 35348 - CAS 123690-79-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Romei, C., et al., 2010. Pharmacol. Res. 61, 547.
Staubli, U., et al., 1999. J. Neurosci. 19, 4609l.
Olpe, H.R., et al. 1990. Eur. J. Pharmacol. 187, 27.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-September-2013 JSW
SynonymsGABAB Receptor Antagonist, CGP 35348, CGP35348, CGP-35348
DescriptionA selective antagonist of post-synaptic GABAB receptors (IC50 = 34 mM) that can permeate the blood brain barrier. Exhibits about 10-fold lower affinity for pre-synaptic receptors. Blocks K+-evoked glycine exocytosis in mouse spinal cord and hippocampal nerve endings. Shown to antagonize the potentiating effect of L-baclofen on noradrenaline-induced stimulation of adenylate cyclase in rat cortex slices.
FormWhite solid
CAS number123690-79-9
Chemical formulaC₈H₂₀NO₄P
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityH₂O (100 mM)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesRomei, C., et al., 2010. Pharmacol. Res. 61, 547.
Staubli, U., et al., 1999. J. Neurosci. 19, 4609l.
Olpe, H.R., et al. 1990. Eur. J. Pharmacol. 187, 27.