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233554 COCO, Mouse, Recombinant

COCO, Mouse, Recombinant MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: DAND5 Dante CKTSF1B3

233554
  
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Overview

Replacement Information

Key Spec Table

Purity
≥90% by SDS-PAGE
Description
Overview

This product has been discontinued.





Recombinant, mouse COCO, consisting of amino acids 24-185 and expressed in E. coli. COCO, a member of the DAN Domain family of BMP antagonists, is able to bind to Xnr1, BMP-4, activin, and Wnt8.
Catalogue Number233554
Brand Family Calbiochem®
SynonymsDAND5 Dante CKTSF1B3
References
ReferencesVonica, A. and A.H. Brivanlou 2007. Dev. Biol. 303, 281.
Baron, M.H. 2005. Exp. Hematol. 33, 1015.
Katoh, M. and M. Katoh 2005. Int. J. Mol. Med. 15, 885.
Kishigami, S. and Y. Mishina 2005. Cytokine Growth Factor Rev. 16, 265.
AvsianKretchmer, O. and A.J.W. Hsueh 2004. Mol. Endocrinol. 18, 1.
De Robertis, E.M. and H. Koruda 2004. Annu. Rev. Cell Dev. Biol. 20, 285.
Katoh, M. and M. Katoh 2004. Oncol. Rep. 12, 423.
Bell, E. et al. 2003. Development 130, 1381.
Pearce, J.J. et al. 1999. Dev. Biol. 209, 98.
Product Information
FormSolid
FormulationLyophilized from 0.2 µm filter-sterilized Acetonitrile, TFA, and BSA.
Applications
Biological Information
Biological activityED₅₀ = 0.6-3 µg/ml as determined by inhibition of BMP-4-induced activity (50 ng/ml BMP-4) in MC3T3-E1 mouse osteoblastic cells.
Purity≥90% by SDS-PAGE
Physicochemical Information
ContaminantsEndotoxin: <1.0 EU/µg protein
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade ITEM Number
Catalogue Number GTIN
233554 0

Documentation

COCO, Mouse, Recombinant Certificates of Analysis

TitleLot Number
233554

References

Reference overview
Vonica, A. and A.H. Brivanlou 2007. Dev. Biol. 303, 281.
Baron, M.H. 2005. Exp. Hematol. 33, 1015.
Katoh, M. and M. Katoh 2005. Int. J. Mol. Med. 15, 885.
Kishigami, S. and Y. Mishina 2005. Cytokine Growth Factor Rev. 16, 265.
AvsianKretchmer, O. and A.J.W. Hsueh 2004. Mol. Endocrinol. 18, 1.
De Robertis, E.M. and H. Koruda 2004. Annu. Rev. Cell Dev. Biol. 20, 285.
Katoh, M. and M. Katoh 2004. Oncol. Rep. 12, 423.
Bell, E. et al. 2003. Development 130, 1381.
Pearce, J.J. et al. 1999. Dev. Biol. 209, 98.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-Sepmtember-2011 RFH
SynonymsDAND5 Dante CKTSF1B3
DescriptionRecombinant, mouse COCO, consisting of amino acids 24-185 and expressed in E. coli. COCO, a member of the DAN Domain family of BMP antagonists, is able to bind to Xnr1, BMP-4, activin, and Wnt8.
FormSolid
FormulationLyophilized from 0.2 µm filter-sterilized Acetonitrile, TFA, and BSA.
Purity≥90% by SDS-PAGE
ContaminantsEndotoxin: <1.0 EU/µg protein
Biological activityED₅₀ = 0.6-3 µg/ml as determined by inhibition of BMP-4-induced activity (50 ng/ml BMP-4) in MC3T3-E1 mouse osteoblastic cells.
SolubilityReconstitute to 100 µg/ml in sterile 35% Acetonitrile, 0.1% TFA containing at least 0.1% human or bovine serum albumin.
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesVonica, A. and A.H. Brivanlou 2007. Dev. Biol. 303, 281.
Baron, M.H. 2005. Exp. Hematol. 33, 1015.
Katoh, M. and M. Katoh 2005. Int. J. Mol. Med. 15, 885.
Kishigami, S. and Y. Mishina 2005. Cytokine Growth Factor Rev. 16, 265.
AvsianKretchmer, O. and A.J.W. Hsueh 2004. Mol. Endocrinol. 18, 1.
De Robertis, E.M. and H. Koruda 2004. Annu. Rev. Cell Dev. Biol. 20, 285.
Katoh, M. and M. Katoh 2004. Oncol. Rep. 12, 423.
Bell, E. et al. 2003. Development 130, 1381.
Pearce, J.J. et al. 1999. Dev. Biol. 209, 98.