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400090 IC261 - CAS 186611-52-9 - Calbiochem

A cell-permeable, reversible, potent and selective inhibitor of casein kinase (CK1) that inhibits CK1δ (IC₅₀ = 0.7-1.3 µM) and CK1ε (IC₅₀ = 0.6-1.4 µM) isozymes.

IC261 - CAS 186611-52-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-[(2,4,6-Trimethoxyphenyl)methylidenyl]-indolin-2-one, SU5607, Casein Kinase I Inhibitor VI

Primary Target: CK1δ
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      186611-52-9C₁₈H₁₇NO₄
      Description
      OverviewA cell-permeable, reversible, potent and selective inhibitor of casein kinase (CK1) that inhibits CK1δ (IC50 = 0.7-1.3 µM) and CK1ε (IC50 = 0.6-1.4 µM) isozymes. Also inhibits CK1α1 at much higher concentrations (IC50 = 11-21 µM). The inhibition is competitive with respect to ATP. Only weakly inhibits PKA, p34cdc2, and p55fyn (IC50s > 100 µM). At low micromolar concentrations, IC261 inhibits cytokinesis causing a transient mitotic arrest.
      Catalogue Number400090
      Brand Family Calbiochem®
      Synonyms3-[(2,4,6-Trimethoxyphenyl)methylidenyl]-indolin-2-one, SU5607, Casein Kinase I Inhibitor VI
      References
      ReferencesBehrend, L., et al. 2000. Oncogene 19, 5303.
      Mashhoon, N., et al. 2000. J. Biol. Chem. 275, 20052.
      Knippschild, U., et al. 1997. Oncogene 15, 1727.
      Product Information
      CAS number186611-52-9
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₁₈H₁₇NO₄
      Chemical formulaC₁₈H₁₇NO₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality SegmentMQ100
      Applications
      Biological Information
      Primary TargetCK1δ
      Primary Target IC<sub>50</sub>0.7-1.3 µM, 0.6-1.4 µM, against CK1δ and CK1ε isozymes, respectively
      Purity≥95% by HPLC (sum of two isomers)
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C when stored under an inert gas.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      400090 0

      Documentation

      IC261 - CAS 186611-52-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      IC261 - CAS 186611-52-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      400090

      References

      Reference overview
      Behrend, L., et al. 2000. Oncogene 19, 5303.
      Mashhoon, N., et al. 2000. J. Biol. Chem. 275, 20052.
      Knippschild, U., et al. 1997. Oncogene 15, 1727.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-December-2009 RFH
      Synonyms3-[(2,4,6-Trimethoxyphenyl)methylidenyl]-indolin-2-one, SU5607, Casein Kinase I Inhibitor VI
      DescriptionA cell-permeable, reversible, potent and selective inhibitor of Casein Kinase (CK1) that inhibits the CK1δ (IC50 = 0.7-1.3 µM) and CK1ε (IC50 = 0.6-1.4 µM) isozymes. Also inhibits CK1α1 at much higher concentrations (IC50 = 11-21 µM). The inhibition is competitive with respect to ATP. Has only a trivial effect on p34cdc2 and p55fyn (IC50s >100 µM). Blocks the phosphorylation of p53 by CK1δ and CK1ε, thereby modulating p53's effect on the cell cycle. At low micromolar concentrations, IC261 inhibits cytokinesis causing a transient mitotic arrest.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number186611-52-9
      Chemical formulaC₁₈H₁₇NO₄
      Structure formulaStructure formula
      Purity≥95% by HPLC (sum of two isomers)
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C when stored under an inert gas.
      Toxicity Standard Handling
      ReferencesBehrend, L., et al. 2000. Oncogene 19, 5303.
      Mashhoon, N., et al. 2000. J. Biol. Chem. 275, 20052.
      Knippschild, U., et al. 1997. Oncogene 15, 1727.