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505208 Methyllycaconitine Citrate - CAS 21019-30-7 - Calbiochem

Methyllycaconitine Citrate - CAS 21019-30-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: AChR Receptor Antagonist, Methyllycaconitine Citrate, alpha7beta2 recptor Antagonist, Methyllycaconitine Citrate, Methyllycaconitine; α7-Nicotinic Receptor Antagonist, Methyllycaconitine Citrate, Neuronal Nicotinic Receptor Antagonist, Methyllycaconitine Citrate

Primary Target: a7 AchR
505208
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
21019-30-7C₃₇H₅₀N₂O₁₀&;bull;C₆H₈O₇
Description
OverviewA potent antagonist highly selective for AChRs with α7 subunit (Ki = 1.4 nM for α7 subunit and > 40 nM for α4β2 and α6β2 receptors). Frequently used in assessing the functional roles of AChRs with α7 subunit in brain functions and disorders (i.e. inflammatory and chronic neuropathic pain and parkinsonian neurodegeneration).
Catalogue Number505208
Brand Family Calbiochem®
SynonymsAChR Receptor Antagonist, Methyllycaconitine Citrate, alpha7beta2 recptor Antagonist, Methyllycaconitine Citrate, Methyllycaconitine; α7-Nicotinic Receptor Antagonist, Methyllycaconitine Citrate, Neuronal Nicotinic Receptor Antagonist, Methyllycaconitine Citrate
References
ReferencesSuzuki, S., et al. 2013. J. Neurosci. Res. 91, 462.
Freitas, K., et al. 2013. Neuropharmacol. 65, 156.
Sheeja, N., et al. 2012. Hippocampus. 22, 335.
Xiong, Y., et al. 2010. Pharmacol. Biochem. & Beha. 95, 192.
Whiteaker, P., et al. 1999. Eur. J. Neurosci. 11, 96.
Product Information
CAS number21019-30-7
FormWhite solid
Hill FormulaC₃₇H₅₀N₂O₁₀&;bull;C₆H₈O₇
Chemical formulaC₃₇H₅₀N₂O₁₀&;bull;C₆H₈O₇
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targeta7 AchR
Primary Target K<sub>i</sub>1.4nM
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade ITEM Number
Catalogue Number GTIN
505208 0

Documentation

Methyllycaconitine Citrate - CAS 21019-30-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Suzuki, S., et al. 2013. J. Neurosci. Res. 91, 462.
Freitas, K., et al. 2013. Neuropharmacol. 65, 156.
Sheeja, N., et al. 2012. Hippocampus. 22, 335.
Xiong, Y., et al. 2010. Pharmacol. Biochem. & Beha. 95, 192.
Whiteaker, P., et al. 1999. Eur. J. Neurosci. 11, 96.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-November-2015 JSW
SynonymsAChR Receptor Antagonist, Methyllycaconitine Citrate, alpha7beta2 recptor Antagonist, Methyllycaconitine Citrate, Methyllycaconitine; α7-Nicotinic Receptor Antagonist, Methyllycaconitine Citrate, Neuronal Nicotinic Receptor Antagonist, Methyllycaconitine Citrate
DescriptionA potent antagonist highly selective for AChRs with α7 subunit (Ki = 1.4 nM for α7 subunit and > 40 nM for α4β2 and α6β2 receptors). Frequently used in assessing the functional roles of AChRs with α7 subunit in brain functions and disorders (i.e. inflammatory and chronic neuropathic pain and parkinsonian neurodegeneration).
FormWhite solid
CAS number21019-30-7
Chemical formulaC₃₇H₅₀N₂O₁₀&;bull;C₆H₈O₇
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityH₂O (100 mM)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSuzuki, S., et al. 2013. J. Neurosci. Res. 91, 462.
Freitas, K., et al. 2013. Neuropharmacol. 65, 156.
Sheeja, N., et al. 2012. Hippocampus. 22, 335.
Xiong, Y., et al. 2010. Pharmacol. Biochem. & Beha. 95, 192.
Whiteaker, P., et al. 1999. Eur. J. Neurosci. 11, 96.