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CBL582-MG-KC Mouse Anti-Human CD19, clone HD37 (1mg) KC

Anti-CD19 Antibody, clone HD37 detects level of CD19 & has been published & validated for use in FC, IP, IH.

CBL582-MG-KC
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      Description
      Catalogue NumberCBL582-MG-KC
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionMouse Anti-Human CD19, clone HD37 (1mg) KC
      OverviewThis product is intended for use by IVD manufacturers.
      Contact customer service for assistance: oem.reagents@emdmillipore.com
      Alternate Names
      • Anti- CD19
      References
      Product Information
      FormatPurified
      PresentationThe monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
      Quality SegmentMQ300
      Applications
      ApplicationAnti-CD19 Antibody, clone HD37 detects level of CD19 & has been published & validated for use in FC, IP, IH.
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      • Immunohistochemistry
      Application NotesIdentification of CD19 positive B lymphocytes and malignant B cells by indirect immunofluorescence staining

      Leukaemia and lymphoma phenotyping

      Identification of normal and malignant CD19 positive B lymphocytes in cryostat frozen sections

      Immunoprecipitation of the CD19 antigen

      Studies of the CD19/21 complex in B cell activation and the control of B cell development

      Optimal working dilutions must be determined by the end user.
      Biological Information
      CloneHD37
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThe CD19 antigen (90 kDa) is expressed from the earliest stages of B-progenitor development, on all peripheral B cells including germinal centre B cells and all B cell lines and B cell leukaemias tested. T cell and monocytic cell lines are negative and the antigen is lost on B cell maturations to plasma cells. The antigen is a type I integral membrane glycoprotein whose in vitro inhibition will influence B cell activation and proliferation.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryLymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
      Gene Symbol
      • CD19
      • B4
      • MGC12802
      • Leu-12
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P15391 # Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
      SIZE: 556 amino acids; 61128 Da
      SUBUNIT: Forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
      DISEASE:SwissProt: P15391 # Defects in CD19 are a cause of hypogammaglobulinemia [MIM:107265].
      SIMILARITY: SwissProt: P15391 ## Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Minimum order quantity required to qualify. Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
      Packaging Information
      Material SizeBulk packaging. Please inquire.
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      CBL582-MG-KC 04053252519963

      Documentation

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies
      IVD/OEM Materials & Reagents > Bulk & Custom Antibodies > Secondary Bulk Antibodies > Anti-Human Antibodies & Conjugates > Mouse Anti-Human
      IVD/OEM Materials & Reagents > Bulk & Custom Antibodies > Primary Bulk Antibodies by Target > Other Primary Bulk Antibodies
      IVD/OEM Materials & Reagents > Bulk & Custom Antibodies > Primary Bulk Antibodies by Target > Tumor Markers & Antigens