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608050 TAS-301

A cell-permeable indolinone compound that displays anti-proliferative properties.

TAS-301 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-bis(4-Methoxyphenyl)methylene-2-indolinone

608050
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
193620-69-8C₂₃H₁₉NO₃
Description
Overview

This product has been discontinued.





A cell-permeable indolinone compound that displays anti-proliferative properties. Potently inhibits growth factor-induced VSMCs (vascular smooth muscle cells) migration and proliferation by blocking voltage-independent Ca2+ influx and downstream signals such as Ca2+/PKC-signaling pathway, leading to AP-1 induction and inhibition of cytoskeletal depolymerization. Reported to prevent neointimal thickening following balloon injury to rat carotid and porcine coronary arteries.
Catalogue Number608050
Brand Family Calbiochem®
Synonyms3-bis(4-Methoxyphenyl)methylene-2-indolinone
References
ReferencesSasaki, E., et al. 2001. Pharmacology 63, 17.
Sasaki, E., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1043.
Sasaki, E., et al. 2000. Jpn. J. Pharmacol. 84, 252.
Muranaka, Y., et al. 1998. J. Pharmacol. Exp. Ther. 285, 1280.
Product Information
CAS number193620-69-8
FormYellow solid
Hill FormulaC₂₃H₁₉NO₃
Chemical formulaC₂₃H₁₉NO₃
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade ITEM Number
Catalogue Number GTIN
608050 0

Documentation

TAS-301 SDS

Title

Safety Data Sheet (SDS) 

TAS-301 Certificates of Analysis

TitleLot Number
608050

References

Reference overview
Sasaki, E., et al. 2001. Pharmacology 63, 17.
Sasaki, E., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1043.
Sasaki, E., et al. 2000. Jpn. J. Pharmacol. 84, 252.
Muranaka, Y., et al. 1998. J. Pharmacol. Exp. Ther. 285, 1280.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
Synonyms3-bis(4-Methoxyphenyl)methylene-2-indolinone
DescriptionA cell-permeable indolinone compound that displays anti-proliferative properties. Potently inhibits growth factor-induced vascular smooth muscle cell (VSMC) migration and proliferation. Reported to block voltage-independent Ca2+ influx and downstream signals such as the Ca2+/PKC-signaling pathway, leading to AP-1 induction and inhibition of cytoskeletal depolymerization. Also reported to prevent neointimal thickening after balloon injury to rat carotid and porcine coronary arteries.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number193620-69-8
Chemical formulaC₂₃H₁₉NO₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) or ethanol
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesSasaki, E., et al. 2001. Pharmacology 63, 17.
Sasaki, E., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1043.
Sasaki, E., et al. 2000. Jpn. J. Pharmacol. 84, 252.
Muranaka, Y., et al. 1998. J. Pharmacol. Exp. Ther. 285, 1280.