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676482 VEGFR Tyrosine Kinase Inhibitor III, KRN633

VEGFR Tyrosine Kinase Inhibitor III, KRN633 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: VEGF Receptor Tyrosine Kinase Inhibitor III, N-(2-Chloro-4-((6,7-dimethoxy-4-quinazolinyl)oxy)phenyl)-Nʹ-propylurea, VEGFR2 Kinase Inhibitor XVIII, VEGFR1 Kinase Inhibitor IV, VEGFR3 Kinase Inhibitor III

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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.

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      A cell-permeable, reversible, ATP-competitive inhibitor of VEGFR kinase activity (IC50 = 170 nM, 160 nM, and 125 nM for VEGFR-1, VEGFR-2, VEGFR-3, respectively). Inhibits PDGFR-α and c-Kit only at higher concentrations (IC50 = 0.97 µM and 4.33 µM, respectively) and is inactive towards a panel of 17 other kinases (IC50 ≥ 10 µM). Shown to suppress VEGF-dependent, but not FGF-dependent, cellular signaling and cell proliferation. Although not cytotoxic to cancer cells, KRN633 exhibits excellent in vivo antitumor activity due to its inhibitory effects on vessel formation and vascular permeability.
      Catalogue Number676482
      Brand Family Calbiochem®
      SynonymsVEGF Receptor Tyrosine Kinase Inhibitor III, N-(2-Chloro-4-((6,7-dimethoxy-4-quinazolinyl)oxy)phenyl)-Nʹ-propylurea, VEGFR2 Kinase Inhibitor XVIII, VEGFR1 Kinase Inhibitor IV, VEGFR3 Kinase Inhibitor III
      References
      ReferencesNakamura, K., et al. 2004. Mol. Cancer Ther. 3, 1639.
      Product Information
      CAS number286370-15-8
      FormWhite solid
      Hill FormulaC₂₀H₂₁ClN₄O₄
      Chemical formulaC₂₀H₂₁ClN₄O₄
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      676482 0

      Documentation

      VEGFR Tyrosine Kinase Inhibitor III, KRN633 Certificates of Analysis

      TitleLot Number
      676482

      References

      Reference overview
      Nakamura, K., et al. 2004. Mol. Cancer Ther. 3, 1639.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-September-2007 JSW
      SynonymsVEGF Receptor Tyrosine Kinase Inhibitor III, N-(2-Chloro-4-((6,7-dimethoxy-4-quinazolinyl)oxy)phenyl)-Nʹ-propylurea, VEGFR2 Kinase Inhibitor XVIII, VEGFR1 Kinase Inhibitor IV, VEGFR3 Kinase Inhibitor III
      DescriptionA cell-permeable, reversible, ATP-competitive inhibitor of VEGFR kinase activity (IC50 = 170 nM, 160 nM, and 125 nM for VEGFR-1, VEGFR-2, VEGFR-3, respectively). Inhibits PDGFR-α and c-Kit only at higher concentrations (IC50 = 0.97 µM and 4.33 µM, respectively) and is inactive towards a panel of 17 other kinases (IC50 ≥ 10 µM). Shown to suppress VEGF-dependent, but not FGF-dependent, cellular signaling and cell proliferation. Although not cytotoxic to cancer cells, KRN633 exhibits excellent in vivo antitumor activity due to its inhibitory effects on vessel formation and vascular permeability.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number286370-15-8
      Chemical formulaC₂₀H₂₁ClN₄O₄
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesNakamura, K., et al. 2004. Mol. Cancer Ther. 3, 1639.