MOUSE SERUM - 4017481
- Document Type:
- Certificate of Analysis
- Lot Number:
- 4017481
- Product Catalog Number:
- S25-100ML
- Product Catalog Name:
- Mouse Serum, 100 ml
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Certificate of Analysis 575545_4051781
- Document Type:
- Certificate of Analysis
- Lot Number:
- 4051781
- Product Catalog Number:
- 575545
- Product Catalog Name:
- Tankyrase1/2 Inhibitor, XAV939 - Calbiochem
-
Certificate of Analysis 420321_4017891
- Document Type:
- Certificate of Analysis
- Lot Number:
- 4017891
- Product Catalog Number:
- 420321
- Product Catalog Name:
- KT5823 - CAS 126643-37-6 - Calbiochem
-
Certificate of Analysis 70666_4019781
- Document Type:
- Certificate of Analysis
- Lot Number:
- 4019781
- Product Catalog Number:
- 70666
- Product Catalog Name:
- Ni-NTA His•Bind® Resin
-
Survival of adult neurons lacking cholesterol synthesis in vivo.
- Cholesterol, an essential component of all mammalian plasma membranes, is highly enriched in the brain. Both during development and in the adult, brain cholesterol is derived from local cholesterol synthesis and not taken up from the circulation. However, the contribution of neurons and glial cells to total brain cholesterol metabolism is unknown.Using conditional gene inactivation in the mouse, we disrupted the squalene synthase gene (fdft1), which is critical for cholesterol synthesis, in cerebellar granule cells and some precerebellar nuclei. Mutant mice showed no histological signs of neuronal degeneration, displayed ultrastructurally normal synapses, and exhibited normal motor coordination. This revealed that these adult neurons do not require cell-autonomous cholesterol synthesis for survival or function.We conclude that at least some adult neurons no longer require endogenous cholesterol synthesis and can fully meet their cholesterol needs by uptake from their surrounding. Glia are a likely source of cholesterol in the central nervous system.
- Document Type:
- Reference
- Product Catalog Number:
- AB5610
-
Certificate of Analysis 1.00681 K51407781
- Document Type:
- Certificate of Analysis
- Lot Number:
- K51407781
- Product Catalog Number:
- 1.00681