m-Endo Total Coliform Broth - A21153
- Document Type:
- Certificate of Quality
- Lot Number:
- A21153
- Product Catalog Number:
- MHA000P2E
- Product Catalog Name:
- m-Endo Total Coliform Broth
a1153
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NU100/31-221-AAM201153
- Document Type:
- Certificate of Quality
- Lot Number:
- AAM201153
- Product Catalog Number:
- NU100/31-221
- Product Catalog Name:
- NA1in V.Body90° 316L el pol
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Anti-C/EBP β (C-term), clone E299, -2679433
- Document Type:
- Certificate of Analysis
- Lot Number:
- 2679433
- Product Catalog Number:
- 04-1153
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CCAAT-enhancer-binding protein β (C/EBPβ) and downstream human placental growth hormone genes are targets for dysregulation in pregnancies complicated by maternal obesity ...
- Human chorionic somatomammotropin (CS) and placental growth hormone variant (GH-V) act as metabolic adaptors in response to maternal insulin resistance, which occurs in "normal" pregnancy. Maternal obesity can exacerbate this "resistance," suggesting that CS, GH-V, or transcription factors that regulate their production might be targets. The human CS genes, hCS-A and hCS-B, flank the GH-V gene. A significant decrease in pre-term placental CS/GH-V RNA levels was observed in transgenic mice containing the CS/GH-V genes in a model of high fat diet (HFD)-induced maternal obesity. Similarly, a decrease in CS/GH-V RNA levels was detected in term placentas from obese (body mass index (BMI) ≥ 35 kg/m(2)) versus lean (BMI 20-25 kg/m(2)) women. A specific decrease in transcription factor CCAAT-enhancer-binding protein β (C/EBPβ) RNA levels was also seen with obesity; C/EBPβ is required for mouse placenta development and is expressed, like CS and GH-V, in syncytiotrophoblasts. Binding of C/EBPβ to the CS gene downstream enhancer regions, which by virtue of their position distally flank the GH-V gene, was reduced in placenta chromatin from mice on a HFD and in obese women; a corresponding decrease in RNA polymerase II associated with CS/GH-V promoters was also observed. Detection of decreased endogenous CS/GH-V RNA levels in human placental tumor cells treated with C/EBPβ siRNA is consistent with a direct effect. These data provide evidence for CS/GH-V dysregulation in acute HFD-induced obesity in mouse pregnancy and chronic obesity in human pregnancy and implicate C/EBPβ, a factor associated with CS regulation and placental development.
- Document Type:
- Reference
- Product Catalog Number:
- 04-1153
-
Certificate of Analysis R04561 1153
- Document Type:
- Certificate of Analysis
- Lot Number:
- 1153
- Product Catalog Number:
- R04561
- Product Catalog Name:
- SAF Fixative
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Certificate of Analysis R04650 1153
- Document Type:
- Certificate of Analysis
- Lot Number:
- 1153
- Product Catalog Number:
- R04650
- Product Catalog Name:
- SAF Fixative
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m-Endo Total Coliform Broth - A21153A
- Document Type:
- Certificate of Quality
- Lot Number:
- A21153A
- Product Catalog Number:
- MHA000P2E
- Product Catalog Name:
- m-Endo Total Coliform Broth