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  • Histones and Histone Modifications | Life Science Research | Merck

    Histone modifications regulate DNA transcription, repair, recombination, and replication, and can alter local chromatin architecture. Understanding histone modifications is key to uncovering epigenetic mechanisms of gene regulation. Merck grasps the complexity of this research and provides a growing line of kits, antibodies, and assays for studying histones and their modifications. Merck offers over 600 validated antibodies, recombinant proteins, and kits to analyze histone and histone-variant phosphorylation, methylation, acetylation, ubiquitination, and citrullination-the most widely studied histone modifications in epigenetics today.
  • DNA Methylation | Life Science Research | Merck

    DNA methylation is involved in the regulation of many cellular processes, including chromosome stability, chromatin structure, X chromosome inactivation, embryonic development, and transcription.
  • DNA Methylation | Life Science Research | Merck

    DNA methylation is involved in the regulation of many cellular processes, including chromosome stability, chromatin structure, X chromosome inactivation, embryonic development, and transcription. DNA methylation occurs mainly at the 5' position of cytosine bases and is mediated by enzymes called DNA methyltransferases (DNMT). Regions of methylated DNA can be bound by a variety of methylated DNA binding proteins (MBD).
  • Histone Modifications | Life Science Research | Merck

    Histone modifications regulate DNA transcription, repair, recombination, and replication, and can alter local chromatin architecture. The most commonly studied histone modifications are acetylation, phosphorylation, methylation, and ubiquitination.
  • CpG Islands | Life Science Research | Merck

    We offer an advanced line of CpG islands kits, antibodies, and reagents that simplifies assays and allows for fast and effective enrichment of target DNA and further genome-wide analyses.