MPTMAG-49K xPonent Protocol Template Version Magpix
- Document Type:
- Technical Information
mptmag-49k
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MPTMAG-49K xPonent Standard Template Version Magpix
- Document Type:
- Technical Information
-
Protocol- MPTMAG-49K
- Document Type:
- Protocols
- Product Catalog Number:
- MPTMAG-49K
- Product Catalog Name:
- MILLIPLEX MAP Mouse Pituitary Magnetic Bead Panel - Endocrine Multiplex Assay
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96 well Template Single
- Document Type:
- Technical Information
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MILLIPLEX MAP Mouse Pituitary Magnetic Bead Panel - Endocrine Multiplex Assay (Iceland)
- Document Type:
- SDS
- Product Catalog Number:
- MPTMAG-49K
- Product Catalog Name:
- MILLIPLEX MAP Mouse Pituitary Magnetic Bead Panel - Endocrine Multiplex Assay
-
MILLIPLEX MAP Mouse Pituitary Magnetic Bead Panel - Endocrine Multiplex Assay (India)
- Document Type:
- SDS
- Product Catalog Number:
- MPTMAG-49K
- Product Catalog Name:
- MILLIPLEX MAP Mouse Pituitary Magnetic Bead Panel - Endocrine Multiplex Assay
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Quality Control Range Sheet- MPIT-116 and MPIT-216
- Document Type:
- Technical Information
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MILLIPLEX MAP Mouse Pituitary Magnetic Bead Panel - Endocrine Multiplex Assay (Malta)
- Document Type:
- SDS
- Product Catalog Number:
- MPTMAG-49K
- Product Catalog Name:
- MILLIPLEX MAP Mouse Pituitary Magnetic Bead Panel - Endocrine Multiplex Assay
-
An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in mice.
- Testis size and sperm production are directly correlated to the total number of adult Sertoli cells (SCs). Although the establishment of an adequate number of SCs is crucial for future male fertility, the identification and characterization of the factors regulating SC survival, proliferation, and maturation remain incomplete. To investigate whether the IGF system is required for germ cell (GC) and SC development and function, we inactivated the insulin receptor (Insr), the IGF1 receptor (Igf1r), or both receptors specifically in the GC lineage or in SCs. Whereas ablation of insulin/IGF signaling appears dispensable for GCs and spermatogenesis, adult testes of mice lacking both Insr and Igf1r in SCs (SC-Insr;Igf1r) displayed a 75% reduction in testis size and daily sperm production as a result of a reduced proliferation rate of immature SCs during the late fetal and early neonatal testicular period. In addition, in vivo analyses revealed that FSH requires the insulin/IGF signaling pathway to mediate its proliferative effects on immature SCs. Collectively, these results emphasize the essential role played by growth factors of the insulin family in regulating the final number of SCs, testis size, and daily sperm output. They also indicate that the insulin/IGF signaling pathway is required for FSH-mediated SC proliferation.
- Document Type:
- Reference
- Product Catalog Number:
- MPTMAG-49K
- Product Catalog Name:
- MILLIPLEX MAP Mouse Pituitary Magnetic Bead Panel - Endocrine Multiplex Assay
-
Quality Control Range Sheet- MPIT-115 and MPIT-215
- Document Type:
- Technical Information