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tyrosine-hydroxylase

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Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 3990647
Document Type:

Certificate of Analysis
Lot Number:

3990647

Product Catalog Number:

MAB318-AF488
Product Catalog Name:

Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 555 Conjugate - 3886614
Document Type:

Certificate of Analysis
Lot Number:

3886614

Product Catalog Number:

MAB318-AF555
Product Catalog Name:

Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 555 Conjugate
Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds.
Electrical stimulation of the medial forebrain bundle increases (32)P incorporation into striatal tyrosine hydroxylase (TH) at Ser (19), Ser(31), and Ser(40). In the present studies, the effects of acute haloperidol and related drugs on sitespecific TH phosphorylation stoichiometry (PS) in the nigrostriatal and mesolimbic systems were determined by quantitative blot immunolabeling using phosphorylation statespecific antibodies. The striatum (Str), substantia nigra (SN), nucleus accumbens (NAc), and ventral tegmental area (VTA) from Sprague-Dawley rats were harvested 30-40 min after a single injection of either vehicle, haloperidol (2 mg/kg), raclopride (2 mg/kg), clozapine (30 mg/kg), or SCH23390 (0.5 mg/kg). In vehicle-injected control rats, Ser(19) PS was 1.5- to 2. 5-fold lower in Str and NAc than in SN and VTA, Ser(31) PS was two-to fourfold higher in Str and NAc than in SN and VTA, and Ser(40) PS was similar between the terminal field and cell body regions. After haloperidol, Ser(40) PS increased twofold in Str and NAc, whereas a smaller increase in SN and VTA was observed. The effects of haloperidol on Ser(19) PS were similar to those on Ser(40) in each region; however, haloperidol treatment increased Ser(31) PS at least 1.6-fold in all regions. The effects of raclopride on TH PS were comparable to those of haloperidol, whereas clozapine treatment increased TH PS at all sites in all regions. By contrast, the effects of SCH23390 on TH PS were relatively small and restricted to the NAc. The stoichiometries of site-specific TH phosphorylation in vivo are presented for the first time. The nigrostriatal and mesolimbic systems have common features of TH PS, distinguished by differences in TH PS between the terminal field and cell body regions and by dissimilar increases in TH PS in the terminal field and cell body regions after acute haloperidol.
Document Type:

Reference

Product Catalog Number:

AB5423
Product Catalog Name:

Anti-Tyrosine Hydroxylase Antibody, phosphoSer31
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 4091251
Document Type:

Certificate of Analysis
Lot Number:

4091251

Product Catalog Number:

MAB318-AF488
Product Catalog Name:

Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 4124273
Document Type:

Certificate of Analysis
Lot Number:

4124273

Product Catalog Number:

MAB318-AF488
Product Catalog Name:

Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 4076671
Document Type:

Certificate of Analysis
Lot Number:

4076671

Product Catalog Number:

MAB318-AF488
Product Catalog Name:

Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 555 Conjugate - 4306085
Document Type:

Certificate of Analysis
Lot Number:

4306085

Product Catalog Number:

MAB318-AF555
Product Catalog Name:

Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 555 Conjugate
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 4318136
Document Type:

Certificate of Analysis
Lot Number:

4318136

Product Catalog Number:

MAB318-AF488
Product Catalog Name:

Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate
Tyrosine hydroxylase gene promoter activity is regulated by both cyclic AMP-responsive element and AP1 sites following calcium influx. Evidence for cyclic amp-responsive ...
Document Type:

Reference

Product Catalog Number:

06-519
Product Catalog Name:

Anti-phospho-CREB (Ser133) Antibody
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 555 Conjugate - 4204605
Document Type:

Certificate of Analysis
Lot Number:

4204605

Product Catalog Number:

MAB318-AF555
Product Catalog Name:

Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 555 Conjugate