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AB5663P Anti-Histamine Receptor 4 Antibody, CT

Anti-Histamine Receptor 4 Antibody, C-terminus detects level of Histamine Receptor 4 & has been published & validated for use in ELISA & WB.

Anti-Histamine Receptor 4 Antibody, CT: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Inflammation & Immunology Research Sub-Category: Inflammation & Autoimmune Mechanisms Gene Symbol: HRH4, H4R, MGC133027, GPCR105, HH4R, GPRv53, H4, AXOR35, SP9144, BG26 UniProt Number: Q9H3N8
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AB5663P
50 µg  
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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5663P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Histamine Receptor 4 Antibody, CT
      Alternate Names
      • H4R
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in PBS with 0.1% BSA.
      Quality SegmentMQ100
      Applications
      ApplicationAnti-Histamine Receptor 4 Antibody, C-terminus detects level of Histamine Receptor 4 & has been published & validated for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 1-10 μg/mL using ECL.

      ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well (Catalog number AG217).

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenA 17 amino acid peptide sequence within the cytoplasmic, C-terminus of human HR4 (Oda et al. 2000; Nakamura et al. 2000).
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes human Histamine Receptor 4 (HR4). The immunogen shows no significant sequence homology with other histamine receptors.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryHistamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H4 belongs to the family 1 of G protein-coupled receptors and has the highest homology to histamine receptor H3 among known G protein-coupled receptors.
      Gene Symbol
      • HRH4
      • H4R
      • MGC133027
      • GPCR105
      • HH4R
      • GPRv53
      • H4
      • AXOR35
      • SP9144
      • BG26
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9H3N8 # The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
      SIZE: 390 amino acids; 44496 Da
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, fetal liver and lymph node.
      SIMILARITY: SwissProt: Q9H3N8 ## Belongs to the G-protein coupled receptor 1 family.
      MISCELLANEOUS: Does not bind diphenhydramine, loratadine, ranitidine, cimetidine and chlorpheniramine. Shows modest affinity for dimaprit, impromidine, clobenpropit, thioperamide, burimamide clozapine, immepip and imetit. The order of inhibitory activity was imetit > clobenpropit > burimamide > thioperamide. Clobenpropit behaves as a partial agonist, dimaprit and impromidine show some agonist activity while clozapine behaves as a full agonist. Thioperamide shows inverse agonism (enhances cAMP activity). The order of inhibitory activity of histamine derivatives was Histamine > N-alpha-methylhistamine > R(-)-alpha- methylhistamine > S(+)-alpha-methylhistamine. Both N-alpha- methylhistamine > R(-)-alpha-methylhistamine behave as full agonists.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Número de referencia GTIN
      AB5663P 04053252367687

      Documentation

      Anti-Histamine Receptor 4 Antibody, CT Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Anti-Histamine Receptor 4 Antibody, CT Certificados de análisis

      CargoNúmero de lote
      RABBIT ANTI-HISTAMINE RECEPTOR 4 (HR4) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2386936 2386936
      RABBIT ANTI-HISTAMINE RECEPTOR 4 (HR4) - 3197708 3197708
      RABBIT ANTI-HISTAMINE RECEPTOR 4 (HR4) - 3209791 3209791
      RABBIT ANTI-HISTAMINE RECEPTOR 4 (HR4) - 4154489 4154489
      RABBIT ANTI-HISTAMINE RECEPTOR 4 (HR4) AFFINITY PURIFIED POLYCLONAL ANTIBODY 2918422
      RABBIT ANTI-HISTAMINE RECEPTOR 4 (HR4) AFFINITY PURIFIED POLYCLONAL ANTIBODY 2956214
      RABBIT ANTI-HISTAMINE RECEPTOR 4 (HR4) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2006043 2006043
      RABBIT ANTI-HISTAMINE RECEPTOR 4 (HR4) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2179314 2179314
      RABBIT ANTI-HISTAMINE RECEPTOR 4 (HR4) AFFINITY PURIFIED POLYCLONAL ANTIBODY - PSO1565998 PSO1565998