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AB9766-200UL Anti-Kv12.1 Antibody

This Anti-Kv12.1 Antibody is validated for use in WB for the detection of Kv12.1.

Anti-Kv12.1 Antibody: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: ELK1 UniProt Number: Q9QWS8
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AB9766-200UL
200 µL  
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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB9766-200UL
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Kv12.1 Antibody
      Alternate Names
      • Elk1
      • KCNH8
      • ether-a-go-go like K+ channel 3
      • Voltage gated K+ channel subfamily H member 8
      References
      Product Information
      FormatAffinity Purified
      Control
      • Included free of charge with the antibody is 40 µg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 µL of sterile deionized water. For negative control, preincubate 1 µg of peptide with 1 µg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
      PresentationAffinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 200 µL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
      Quality SegmentMQ100
      Applications
      ApplicationThis Anti-Kv12.1 Antibody is validated for use in WB for the detection of Kv12.1.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:200 using ECL on rat cortex lysate.
      Dilutions should be made using a carrier protein such as BSA (1-3%).

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenPurified peptide from amino acids 143-157 of rat Kv12.1 .
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes Kv12.1 (Elk1, KCNH8, ether-a-go-go like K+ channel 3, Voltage gated K+ channel subfamily H member 8).
      Species Reactivity
      • Human
      • Rat
      Species Reactivity NoteThe immunogen sequence is 14 of 15 amino acids identical in mouse.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ELK1
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFunction: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.
      Subunit structure: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.
      Subcellular location: Membrane; Multi-pass membrane protein.
      Tissue specificity: Detected in superior cervical, mesenteric and coeliac ganglia. Expressed in brain (piriform cortex, olfactory tubercle, cerebral cortex, hippocampus pyramidial cells and dentate gyrus and basal ganglia of caudate/putamen and accumbens nucleus). Expressed in pituitary.
      Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
      Sequence similarities: Belongs to the potassium channel family. H (Eag) subfamily.
      Contains 1 cyclic nucleotide-binding domain.
      Contains 1 PAC (PAS-associated C-terminal) domain.
      Contains 1 PAS (PER-ARNT-SIM) domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Número de referencia GTIN
      AB9766-200UL 04053252733802