Millipore Sigma Vibrant Logo
Atención: Nos hemos mudado. Los productos Merck Millipore ya no pueden adquirirse en MerckMillipore.comMás información

MABN630 Anti-SDHA Antibody, clone 7H11.2

Anti-SDHA, clone 7H11.2 is an antibody against SDHA for use in WB, IH.

Anti-SDHA Antibody, clone 7H11.2: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: SDHA, SDH2, SDHF UniProt Number: P31040
View Products on Sigmaaldrich.com
MABN630
100 µg  
Purchase on Sigma-Aldrich

Ofertas especiales

Descripción

Replacement Information

Ofertas especiales

100% Performance Guaranteed

Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWB, IHCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABN630
DescriptionAnti-SDHA Antibody, clone 7H11.2
Alternate Names
  • Flavoprotein subunit of complex II
  • Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Background InformationSDHA, also known as Succinate dehydrogenase flavoprotein-mitochondrial subunit, or Flavoprotein subunit of complex II (Fp), and encoded by the gene symbol SDHA/ SDH2/ SDHF, is a member of the FAD-dependent oxidoreductase 2 family and the FRD/SDH subfamily. Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) is involved in the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Recent studies have indicated that SDHA may act as a tumor suppressor. SDHA is composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. SDHA interacts with SDHAF2/SDH5 in the process required for FAD attachment. Additionally, FDHA has been shown to interact with TRAP1. Mutations in the SDHA gene have been associated with Mitochondrial complex II deficiency (MT-C2D), a disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations. Additionally, mutations in the SDHA gene have been implied in Leigh syndrome or Kearns-Sayre syndrome, Cardiomyopathy dilated 1GG (CMD1GG), and Paragangliomas 5 (PGL5).
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality SegmentMQ100
Applications
ApplicationAnti-SDHA, clone 7H11.2 is an antibody against SDHA for use in WB, IH.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesWestern Blotting Analysis: A 0.5 µg/mL dilution from a representative lot detected SDHA in 10 µg of C2C12 and HeLa cell lysates.
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected SDHA in human cerebral cortex and human cardiac myocytes tissues.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to the C-terminus of Human SDHA.
EpitopeImmunogen is near the C-terminal.
Clone7H11.2
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG2aκ
Species Reactivity
  • Human
  • Mouse
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • SDHA
  • SDH2
  • SDHF
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~68 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in Human brain tissue lysate.

Western Blotting Analysis: A 0.5 µg/mL diultion of this antibody detected SDHA in 10 µg of Human brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade ITEM Number
Número de referencia GTIN
MABN630 04055977113662