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AB3353 Anti-SUV39H1 Antibody

Use Anti-SUV39H1 Antibody (Rabbit Polyclonal Antibody) validated in ELISA, WB to detect SUV39H1 also known as KMT1A, Histone H3-K9 Methyltransferase 1.

Anti-SUV39H1 Antibody: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Histones Gene Symbol: SUV39H1, SUV39H, Su, KMT1A, MG44, EC 2.1.1.43 UniProt Number: O43463
AB3353
100 µg  
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      Descripción

      Replacement Information
      Replacement InformationMABE552 is the recommended replacement for Discontinued catalog number AB3353

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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB3353
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-SUV39H1 Antibody
      Alternate Names
      • Suppressor of Variegation 3-9 Homolog
      • KMT1A
      • Histone H3-K9 Methyltransferase 1
      References
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin. Liquid in PBS containing 0.09% sodium azide.
      Applications
      ApplicationUse Anti-SUV39H1 Antibody (Rabbit Polyclonal Antibody) validated in ELISA, WB to detect SUV39H1 also known as KMT1A, Histone H3-K9 Methyltransferase 1.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern Blot: 1:100-1:500. Predicted molecular weight 47 kDa.

      ELISA (direct): 1:1,000

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenGST fusion protein from the N-terminal of human SUV39H1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityReacts with SUV39H1.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.
      Gene Symbol
      • SUV39H1
      • SUV39H
      • Su
      • KMT1A
      • MG44
      • EC 2.1.1.43
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O43463 # Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiaton, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length.


      SIZE: 412 amino acids; 47907 Da

      SUBUNIT: Interacts with H3 and H4 histones. Interacts with GFI1B, DNMT3B, CBX1, CBX4, MBD1, RUNX1, RUNX3, MYOD1, SMAD5 and RB1. Interacts with SBF1 through the SET domain. Interacts with HDAC1 and HDAC2 through the N-terminus and associates with the core histone deacetylase complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. In case of infection, interacts with HTLV-1 Tax protein, leading to abrogate Tax transactivation of HTLV-1 LTR.

      SUBCELLULAR LOCATION: Nucleus. Note=Associates with centromeric constitutive heterochromatin.

      DEVELOPMENTAL STAGE: Accumulates during mitosis at centromeres during prometaphase, but dissociates from the centromere at the meta- to anaphase transition.

      DOMAIN: SwissProt: O43463 Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin.

      PTM: Phosphorylated on serine residues, and to a lesser degree, on threonine residues. The phosphorylated form is stabilized by SBF1 and is less active in its transcriptional repressor function.


      SIMILARITY: Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. & Contains 1 chromo domain. & Contains 1 post-SET domain. & Contains 1 pre-SET domain. & Contains 1 SET domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Número de referencia GTIN
      AB3353 04053252286506

      Documentation

      Anti-SUV39H1 Antibody Certificados de análisis

      CargoNúmero de lote
      RABBIT ANTI-SUV39H1 POLYCLONAL ANTIBODY - 2197122 2197122

      Referencias bibliográficas

      Visión general referenciasPub Med ID
      Histone methyltransferases, diet nutrients and tumour suppressors.
      Huang, Shi
      Nat. Rev. Cancer, 2: 469-76 (2002)  2002

      		12189389 12189389
      Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase.
      Wang, H, et al.
      Mol. Cell, 8: 1207-17 (2001)  2001

      Mostrar resumen       		11779497 11779497

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies