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218759 Caspase-8 Inhibitor II - Calbiochem

Caspase-8 Inhibitor II, CAS 210344-98-2, is a potent, cell-permeable, irreversible inhibitor of caspase-8 and granzyme B.

Caspase-8 Inhibitor II - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Z-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III

Primary Target: caspase-8
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218759
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₃₀H₄₃FN₄O₁₁

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
218759-1MG
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      		 Ampolla de plást. 1 mg
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      218759-250UG
      Comprobando disponibilidad...
      —
      Disponibilidad a confirmar Disponibilidad a confirmar
      En existencia 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente
          Contact Customer Service

          		 Frasco de vidrio 250 μg
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          Description
          OverviewA potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218840) in DMSO is also available.
          Catalogue Number218759
          Brand Family Calbiochem®
          SynonymsZ-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III
          References
          ReferencesTakizawa, T., et al. 1999. Microbiol. Immunol. 43, 245.
          Martin, D.A., et al. 1998. J. Biol. Chem. 273, 4345.
          Sweeney, E.A., et al. 1998. FEBS Lett. 425, 61.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Product Information
          ATP CompetitiveN
          FormWhite to yellow powder
          Hill FormulaC₃₀H₄₃FN₄O₁₁
          Chemical formulaC₃₀H₄₃FN₄O₁₁
          HS Code2924 29 99
          ReversibleN
          Quality SegmentMQ100
          Applications
          ApplicationCaspase-8 Inhibitor II, CAS 210344-98-2, is a potent, cell-permeable, irreversible inhibitor of caspase-8 and granzyme B.
          Biological Information
          Primary Targetcaspase-8
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceZ-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 8 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade ITEM Number
          Número de referencia GTIN
          218759-1MG 04055977218619
          218759-250UG 04055977218626

          Documentation

          Licencias necesarias

          Título
          PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

          Caspase-8 Inhibitor II - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Caspase-8 Inhibitor II - Calbiochem Certificados de análisis

          CargoNúmero de lote
          218759

          Referencias bibliográficas

          Visión general referencias
          Takizawa, T., et al. 1999. Microbiol. Immunol. 43, 245.
          Martin, D.A., et al. 1998. J. Biol. Chem. 273, 4345.
          Sweeney, E.A., et al. 1998. FEBS Lett. 425, 61.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

          Folleto

          Cargo
          Caspases and other Apoptosis Related Tools Brochure

          Citas

          Título
        • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
        • Kira Steigerwald, et al. (2005) The APC tumor suppressor promotes transcription-independent apoptosis in vitro. Molecular Cancer Research 3, 78-89.
        • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
        • Ashish K. Sharma and Baerbel Rohrer. (2004) Calcium-induced Calpain Mediates Apoptosis via Caspase-3 in a Mouse Photoreceptor Cell Line. Journal of Biological Chemistry 279, 35564-35572.
        • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.
          		•
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-November-2023 JSW
          SynonymsZ-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III
          DescriptionA potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.
          FormWhite to yellow powder
          Chemical formulaC₃₀H₄₃FN₄O₁₁
          Peptide SequenceZ-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*
          Purity≥98% by HPLC
          SolubilityDMSO (10 mM)
          Storage Protect from moisture
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 8 months at -20°C.
          Toxicity Standard Handling
          ReferencesTakizawa, T., et al. 1999. Microbiol. Immunol. 43, 245.
          Martin, D.A., et al. 1998. J. Biol. Chem. 273, 4345.
          Sweeney, E.A., et al. 1998. FEBS Lett. 425, 61.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Citation
        • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
        • Kira Steigerwald, et al. (2005) The APC tumor suppressor promotes transcription-independent apoptosis in vitro. Molecular Cancer Research 3, 78-89.
        • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
        • Ashish K. Sharma and Baerbel Rohrer. (2004) Calcium-induced Calpain Mediates Apoptosis via Caspase-3 in a Mouse Photoreceptor Cell Line. Journal of Biological Chemistry 279, 35564-35572.
        • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.
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