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218761 Caspase-9 Inhibitor I - Calbiochem

Caspase-9 Inhibitor I, CAS 210345-04-3, is a potent, cell-permeable, and irreversible inhibitor of caspase-9.

Caspase-9 Inhibitor I - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Z-LE(OMe)HD(OMe)-FMK

Primary Target: caspase-4, caspase-5, caspase-9
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₃₂H₄₃FN₆O₁₀
Description
Overview

This product has been discontinued.



A potent, cell-permeable, and irreversible inhibitor of caspase-9. May also inhibit caspase-4 and caspase-5. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/72 µl) solution of Z-LEHD-FMK (Cat. No. 218841) in DMSO is also available.
Catalogue Number218761
Brand Family Calbiochem®
SynonymsZ-LE(OMe)HD(OMe)-FMK
References
ReferencesFadeel, B., et al. 1999. Leukemia 13, 719.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Product Information
ATP CompetitiveN
FormWhite to light brown solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₃₂H₄₃FN₆O₁₀
Chemical formulaC₃₂H₄₃FN₆O₁₀
ReversibleN
Quality SegmentMQ100
Applications
ApplicationCaspase-9 Inhibitor I, CAS 210345-04-3, is a potent, cell-permeable, and irreversible inhibitor of caspase-9.
Biological Information
Primary Targetcaspase-4, caspase-5, caspase-9
Puritysingle spot by TLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Leu-Glu(OMe)-His-Asp(OMe)-CH₂F*
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade ITEM Number
Número de referencia GTIN
218761 0

Documentation

Caspase-9 Inhibitor I - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Caspase-9 Inhibitor I - Calbiochem Certificados de análisis

CargoNúmero de lote
218761

Referencias bibliográficas

Visión general referencias
Fadeel, B., et al. 1999. Leukemia 13, 719.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

Folleto

Cargo
Caspases and other Apoptosis Related Tools Brochure

Citas

Título
  • Kira Steigerwald, et al. (2005) The APC tumor suppressor promotes transcription-independent apoptosis in vitro. Molecular Cancer Research 3, 78-89.
  • Ashish K. Sharma and Baerbel Rohrer. (2004) Calcium-induced Calpain Mediates Apoptosis via Caspase-3 in a Mouse Photoreceptor Cell Line. Journal of Biological Chemistry 279, 35564-35572.
  • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.
    		•
    Ficha técnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision04-June-2008 RFH
    SynonymsZ-LE(OMe)HD(OMe)-FMK
    DescriptionA potent, cell-permeable, and irreversible inhibitor of caspase-9.
    FormWhite to light brown solid
    FormulationSupplied as a trifluoroacetate salt.
    Chemical formulaC₃₂H₄₃FN₆O₁₀
    Peptide SequenceZ-Leu-Glu(OMe)-His-Asp(OMe)-CH₂F*
    Puritysingle spot by TLC
    SolubilityDMSO (10 mg/ml)
    Storage Protect from moisture
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesFadeel, B., et al. 1999. Leukemia 13, 719.
    Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
    Citation
  • Kira Steigerwald, et al. (2005) The APC tumor suppressor promotes transcription-independent apoptosis in vitro. Molecular Cancer Research 3, 78-89.
  • Ashish K. Sharma and Baerbel Rohrer. (2004) Calcium-induced Calpain Mediates Apoptosis via Caspase-3 in a Mouse Photoreceptor Cell Line. Journal of Biological Chemistry 279, 35564-35572.
  • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.
    		•