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454585 NMDA Receptor NR2BCT(1292-1304)-TAT - Calbiochem

A 13-mer NMDA receptor 2B (NR2B) subunit carboxy terminal (1292-1304) derived peptide that specifically binds DAPK1 in a reversible manner and antagonizes the activated DAPK1-NR2B interaction and the potentiation of NMDAR function

NMDA Receptor NR2BCT(1292-1304)-TAT - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: H-KKNRNKLRRQHSY-Ahx-YGRKKRRQRRR-NH₂, Tat-NR2BCT

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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₁₄₃H₂₅₄N₆₄O₃₂
Description
Overview

This product has been discontinued.



A 13-mer NMDA receptor 2B (NR2B) subunit carboxy terminal (1292-1304) derived peptide that specifically binds DAPK1 (death-associated protein kinase 1) in a reversible manner and antagonizes the activated DAPK1-NR2B interaction and the potentiation of NMDAR function with no effect on either the catalytic activity of DAPK1 or the NMDA receptor physiology. Blocks Ca2+ influx through extrasynaptic NMDA receptors (at 50 µM) and the blood-brain-barrier permeable version, namely NR2BCT(1292-1304) attached to TAT(47-57) via a spacer (6-aminohexanoic acid) protects cortical neurons from NMDA receptor-mediated insults and reduces brain infarction and improve neurological functions in mice (10 mg/kg, i.v.).
Catalogue Number454585
Brand Family Calbiochem®
SynonymsH-KKNRNKLRRQHSY-Ahx-YGRKKRRQRRR-NH₂, Tat-NR2BCT
References
ReferencesTu, W., et al. Cell 140, 222.
Product Information
FormWhite powder
FormulationSupplied as a trifluoroacetate salt
Hill FormulaC₁₄₃H₂₅₄N₆₄O₃₂
Chemical formulaC₁₄₃H₂₅₄N₆₄O₃₂
Hygroscopic Hygroscopic
Quality SegmentMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Peptide SequenceH₂N-Lys-Lys-Asn-Arg-Asn-Lys-Leu-Arg-Arg-Gln-His-Ser-Tyr-Ahx-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-CONH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade ITEM Number
Número de referencia GTIN
454585 0

Documentation

NMDA Receptor NR2BCT(1292-1304)-TAT - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

NMDA Receptor NR2BCT(1292-1304)-TAT - Calbiochem Certificados de análisis

CargoNúmero de lote
454585

Referencias bibliográficas

Visión general referencias
Tu, W., et al. Cell 140, 222.

Folleto

Cargo
Pathways and Biomarkers of Glutamatergic Synapse Flyer
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-July-2012 JSW
SynonymsH-KKNRNKLRRQHSY-Ahx-YGRKKRRQRRR-NH₂, Tat-NR2BCT
DescriptionA 13-mer NMDA receptor 2B (NR2B) subunit carboxy terminal (1292-1304) derived peptide that specifically binds DAPK1 (death-associated protein kinase 1) in a reversible manner and antagonizes the activated DAPK1-NR2B interaction and the potentiation of NMDAR function with no effect on either the catalytic activity of DAPK1 or the NMDA receptor physiology. Blocks Ca2+ influx through extrasynaptic NMDA receptors (at 50 µM) and the blood-brain-barrier permeable version, namely NR2BCT(1292-1304) attached to TAT(47-57) via a spacer (6-aminohexanoic acid) protects cortical neurons from NMDA receptor-mediated insults and reduces brain infarction and improve neurological functions in mice (10 mg/kg, i.v.).
FormWhite powder
FormulationSupplied as a trifluoroacetate salt
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₄₃H₂₅₄N₆₄O₃₂
Peptide SequenceH₂N-Lys-Lys-Asn-Arg-Asn-Lys-Leu-Arg-Arg-Gln-His-Ser-Tyr-Ahx-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-CONH₂
Purity≥98% by HPLC
SolubilityH,sub>2O (50 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTu, W., et al. Cell 140, 222.