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MABT1496-25UG Anti-Plakophilin-3 Antibody, clone 7F6

Anti-Plakophilin-3, clone 7F6, Cat. No. MABT1496, is a mouse monoclonal antibody that detect Plakophilin-3 and has been tested for use in Western Blotting.

Anti-Plakophilin-3 Antibody, clone 7F6 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Cell Structure Gene Symbol: PKP3 UniProt Number: Q9Y446
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MABT1496-25UG
25 μg  
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      Replacement Information

      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABT1496-25UG
      DescriptionAnti-Plakophilin-3 Antibody, clone 7F6
      Alternate Names
      • PKP3
      • Plakophilin 3
      Background InformationPlakophilin-3 (UniProt: Q9Y446; also known as PKP3) is encoded by the PKP3 gene (Gene ID: 11187) in human. Plakophilin 3 a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells and dendritic reticular cells of lymphatic follicles. Plakophilin-3 is an Armadillo-like protein whose expression pattern is largely restricted to epithelial cell types and plays a role in junctional plaques. It is localized in the desmosomal plaques and in the nucleus. Plakophilin-3 contains a central Arm repeat domain, containing 10 Arm repeats and a short C-terminal domain. Plakophilin proteins act in a cellular desmosome-dependent adhesion and signaling pathways. It is shown to bind directly to the desmosomal cadherins Dsg1, Dsg2, Dsg3, Dsc3a, and Dsc3b, and possibly also to Dsc1a and Dsc2a. Two isoforms of Plakophiln-3 have been described that are produced by alternative splicing. Isoform PKP3a is found in desmosomes of most simple and stratified epithelia and PKP3b is abundant in the stratified epithelial cells, but not in simple epithelial cells. Plakophilin-3 levels are up-regulated in lung carcinogenesis. (Ref.: Bonne, S., et al. (1999). J. Cell Sci. 112(1); 2265-2276; Furukawa, C., et al. (2005). Cancer Res. 65(16); 7102-7110).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Plakophilin-3, clone 7F6, Cat. No. MABT1496, is a mouse monoclonal antibody that detect Plakophilin-3 and has been tested for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenMBP-tagged recombinant fragment corresponding to the first 308 amino acids from human Plakophilin-3.
      Clone7F6
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 7F6 specifically detects human Plakophilin-3. It targets an epitope with in the N-terminal half.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PKP3
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~95 kDa observed; 87.08 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HaCaT cell lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected Plakophilin-3 in HaCaT cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Référence GTIN
      MABT1496-25UG 04054839557927