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504277 CB2 Inverse Agonist, SR 144528 - CAS 192703-06-3 - Calbiochem

CB2 Inverse Agonist, SR 144528 - CAS 192703-06-3 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 5-​(4-​chloro-​3-​methylphenyl)-​1-​[(4-​methylphenyl)methyl]-​N-​[(1S,​2S,​4R)-​1,​3,​3-​trimethylbicyclo[2.2.1]hept-​2-​yl]-​1H-​pyrazole-3

Primary Target: CB₂ Receptor
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      192703-06-3C₂₉H₃₄ClN₃O
      Description
      Overview

      This product has been discontinued.



      A selective inverse agonist for peripheral cannabinoid (CB2) receptors (Ki = 0.6 nM and 400 nM for CB2 and CB1 receptors, respectively). Has been used in studies related to control of pain initiation, suppression of inflammation, and immune activation.
      Catalogue Number504277
      Brand Family Calbiochem®
      Synonyms5-​(4-​chloro-​3-​methylphenyl)-​1-​[(4-​methylphenyl)methyl]-​N-​[(1S,​2S,​4R)-​1,​3,​3-​trimethylbicyclo[2.2.1]hept-​2-​yl]-​1H-​pyrazole-3
      References
      ReferencesBarth, F., et al. 1999. Curr. Med. Chem. 6, 745.
      Iwamura, H., et al. 2001. J. Pharmacol. Exp. Ther. 296, 420.
      Wright, K., et al. 2008. Br. J. Pharmacol. 153, 263.
      Di Marzo, V. 2008. Nat. Rev. Drug Discov. 7, 438.
      Rinaldi-Carmona, M., et al. 1998. J. Pharmacol. Exp. Ther. 284, 644.
      Portier, M., et al. 1999. J. Pharmacol. Exp. Ther. 288, 582.
      Product Information
      CAS number192703-06-3
      FormOff-white solid
      Hill FormulaC₂₉H₃₄ClN₃O
      Chemical formulaC₂₉H₃₄ClN₃O
      Structure formula ImageStructure formula Image
      Quality SegmentMQ100
      Applications
      Biological Information
      Primary TargetCB₂ Receptor
      Primary Target K<sub>i</sub>0.6 nM and 400 nM for CB₂ and CB₁ receptors, respectively.
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Référence GTIN
      504277 0

      Documentation

      CB2 Inverse Agonist, SR 144528 - CAS 192703-06-3 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Barth, F., et al. 1999. Curr. Med. Chem. 6, 745.
      Iwamura, H., et al. 2001. J. Pharmacol. Exp. Ther. 296, 420.
      Wright, K., et al. 2008. Br. J. Pharmacol. 153, 263.
      Di Marzo, V. 2008. Nat. Rev. Drug Discov. 7, 438.
      Rinaldi-Carmona, M., et al. 1998. J. Pharmacol. Exp. Ther. 284, 644.
      Portier, M., et al. 1999. J. Pharmacol. Exp. Ther. 288, 582.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-June-2013 JSW
      Synonyms5-​(4-​chloro-​3-​methylphenyl)-​1-​[(4-​methylphenyl)methyl]-​N-​[(1S,​2S,​4R)-​1,​3,​3-​trimethylbicyclo[2.2.1]hept-​2-​yl]-​1H-​pyrazole-3
      DescriptionA selective inverse agonist for peripheral cannabinoid (CB2) receptors (Ki = 0.6 nM and 400 nM for CB2 and CB1 receptors, respectively). Has been used in studies related to control of pain initiation, suppression of inflammation, and immune activation.
      FormOff-white solid
      CAS number192703-06-3
      Chemical formulaC₂₉H₃₄ClN₃O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (20 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBarth, F., et al. 1999. Curr. Med. Chem. 6, 745.
      Iwamura, H., et al. 2001. J. Pharmacol. Exp. Ther. 296, 420.
      Wright, K., et al. 2008. Br. J. Pharmacol. 153, 263.
      Di Marzo, V. 2008. Nat. Rev. Drug Discov. 7, 438.
      Rinaldi-Carmona, M., et al. 1998. J. Pharmacol. Exp. Ther. 284, 644.
      Portier, M., et al. 1999. J. Pharmacol. Exp. Ther. 288, 582.