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252750 Deferoxamine Mesylate - CAS 138-14-7 - Calbiochem

Iron chelating agent

Deferoxamine Mesylate - CAS 138-14-7 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Desferrioxamine Mesylate, DFOM, Iron Chelator II

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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      138-14-7C₂₅H₄₈N₆O₈·CH₄O₃S
      Description
      OverviewIron chelating agent. Completely protects against dopamine-induced cell death. Has also been shown to interfere with hydroxyl radical formation, which mediates tissue damage in several disease states. Shows anti-proliferative effect on vascular smooth muscle cells in vitro and in vivo. Can also inhibit the oxidative chemistry of peroxynitrite by reaction of the hydroxamic acid moieties with trans-peroxynitrous acid.
      Catalogue Number252750
      Brand Family Calbiochem®
      SynonymsDesferrioxamine Mesylate, DFOM, Iron Chelator II
      References
      ReferencesBergeron, R.J., et al. 1996. J. Med. Chem. 39, 1575.
      Ben-Shachar, D., et al. 1995. J. Neurochem. 64, 718.
      Denicola, A., et al. 1995. Free Radic. Biol. Med. 19, 11.
      Dzwigaj, S., and pererat, H., 1995. Free Radic. Res. 14, 103.
      Dang, S., et al. 1994. Res. Commun. Mol. Pathol. Pharmacol. 86, 43.
      Porreca, E., et al. 1994. Arterioscler. Thromb. 14, 299.
      Product Information
      CAS number138-14-7
      FormFaint yellow powder
      Hill FormulaC₂₅H₄₈N₆O₈·CH₄O₃S
      Chemical formulaC₂₅H₄₈N₆O₈·CH₄O₃S
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality SegmentMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUG5310000
      Safety Information
      R PhraseR: 22-36/37/38-40-42/43

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      Limited evidence of a carcinogenic effect.
      May cause sensitization by inhalation and skin contact.
      S PhraseS: 22-26-36

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Référence GTIN
      252750 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Deferoxamine Mesylate - CAS 138-14-7 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Deferoxamine Mesylate - CAS 138-14-7 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      252750

      Références bibliographiques

      Aperçu de la référence bibliographique
      Bergeron, R.J., et al. 1996. J. Med. Chem. 39, 1575.
      Ben-Shachar, D., et al. 1995. J. Neurochem. 64, 718.
      Denicola, A., et al. 1995. Free Radic. Biol. Med. 19, 11.
      Dzwigaj, S., and pererat, H., 1995. Free Radic. Res. 14, 103.
      Dang, S., et al. 1994. Res. Commun. Mol. Pathol. Pharmacol. 86, 43.
      Porreca, E., et al. 1994. Arterioscler. Thromb. 14, 299.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-February-2024 JSW
      SynonymsDesferrioxamine Mesylate, DFOM, Iron Chelator II
      DescriptionParenteral iron chelating agent. Commonly used in therapy as a chelator of ferric iron in disorders of iron overload. Completely protects against dopamine-induced cell death. Has also been shown to interfere with hydroxyl radical formation, which mediates tissue damage in several disease states. Shows antiproliferative effects on vascular smooth muscle cells in vitro and in vivo. Can also inhibit the oxidative chemistry of peroxynitrite by reaction of the hydroxamic moieties with trans-peroxynitrous acid.
      FormFaint yellow powder
      CAS number138-14-7
      RTECSUG5310000
      Chemical formulaC₂₅H₄₈N₆O₈·CH₄O₃S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (50 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 2860
      ReferencesBergeron, R.J., et al. 1996. J. Med. Chem. 39, 1575.
      Ben-Shachar, D., et al. 1995. J. Neurochem. 64, 718.
      Denicola, A., et al. 1995. Free Radic. Biol. Med. 19, 11.
      Dzwigaj, S., and pererat, H., 1995. Free Radic. Res. 14, 103.
      Dang, S., et al. 1994. Res. Commun. Mol. Pathol. Pharmacol. 86, 43.
      Porreca, E., et al. 1994. Arterioscler. Thromb. 14, 299.