400083 Sigma-AldrichHIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem
The HIF-1 Inhibitor, also referenced under CAS 934593-90-5, controls the biological activity of HIF-1.
More>> The HIF-1 Inhibitor, also referenced under CAS 934593-90-5, controls the biological activity of HIF-1. Less<<HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: CAY10585, 3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester, Hypoxia-Inducible Factor-1 Inhibitor, LW6
Produits recommandés
Aperçu
| Replacement Information |
|---|
Tableau de caractéristiques principal
| CAS # | Empirical Formula |
|---|---|
| 934593-90-5 | C₂₆H₂₉NO₅ |
Products
| Référence | Conditionnement | Qté | |
|---|---|---|---|
| 400083-10MG | Flacon en verre | 10 mg |
| Description | |
|---|---|
| Overview | A cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6 µM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein, while exhibiting no apparent effect on the cellular level of HIF-1α mRNA or that of HIF-1β protein. Shown to inhibit malate dehydrogenase 2 (MDH2) activity and suppress mitochondrial respiration. Also available as a 25 mM solution in DMSO (Cat. No. 400092). |
| Catalogue Number | 400083 |
| Brand Family | Calbiochem® |
| Synonyms | CAY10585, 3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester, Hypoxia-Inducible Factor-1 Inhibitor, LW6 |
| References | |
|---|---|
| References | Lee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press. Lee, K. et. al. 2010. Biochem. Pharmacol. 80, 982. Lee, K., et al. 2007. J. Med. Chem. 50, 1675. |
| Product Information | |
|---|---|
| CAS number | 934593-90-5 |
| Form | Light beige powder |
| Hill Formula | C₂₆H₂₉NO₅ |
| Chemical formula | C₂₆H₂₉NO₅ |
| HS Code | 2924 29 99 |
| Structure formula Image | |
| Quality Segment | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Purity | ≥98% by HPLC |
| Physicochemical Information |
|---|
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade ITEM Number | |
|---|---|
| Référence | GTIN |
| 400083-10MG | 07790788049980 |
Documentation
HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
|---|---|
| 400083 |
Références bibliographiques
| Aperçu de la référence bibliographique |
|---|
| Lee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press. Lee, K. et. al. 2010. Biochem. Pharmacol. 80, 982. Lee, K., et al. 2007. J. Med. Chem. 50, 1675. |