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504479 JNJ 16259685 - CAS 409345-29-5 - Calbiochem

JNJ 16259685 - CAS 409345-29-5 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone

Primary Target: mGlu₁
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
409345-29-5C₂₀H₂₃NO₃
Description
OverviewAn extremely potent, non-competitive antagonist for mGlu receptor subtype 1 (Ki = 0.34 nM; IC50 = 0.55 nM). 400-fold more selective for mGlu1 than for mGlu5 and no interaction with mGlu2, mGlu3, mGlu4, mGlu6, AMPA or NMDA receptors (IC50 >10 µM). Centrally active following systemic administration. Widely used for studying substance abuse, learning and memory, and neural plasticity.
Catalogue Number504479
Brand Family Calbiochem®
Synonyms(3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
References
ReferencesLavreysen, H., et al. 2004. Neuropharmacology. 47, 961.
Steckler, T., et al. 2005. Psychopharmacology. 179, 198.
Steckler, T., et al. 2005. Behav. Brain. Res. 164, 52.
Mabire, D., et al. 2005. J. Med. Chem. 48, 2134.
Fukunaga, I., et al. 2007. Br. J. Pharmacol. 151, 870.
Knopfel, T., et al. 2007. Br. J. Pharmacol. 151, 723.
Achat-Mendes, C., et al. 2012. J. Pharmacol. Exp. Ther. 343, 214.
Product Information
CAS number409345-29-5
FormWhite to off-white solid
Hill FormulaC₂₀H₂₃NO₃
Chemical formulaC₂₀H₂₃NO₃
Structure formula ImageStructure formula Image
Quality SegmentMQ100
Applications
Biological Information
Primary TargetmGlu₁
Primary Target IC<sub>50</sub>0.55 nM
Primary Target K<sub>i</sub>0.34nM
Purity≥98% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade ITEM Number
Référence GTIN
504479 0

Documentation

JNJ 16259685 - CAS 409345-29-5 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Références bibliographiques

Aperçu de la référence bibliographique
Lavreysen, H., et al. 2004. Neuropharmacology. 47, 961.
Steckler, T., et al. 2005. Psychopharmacology. 179, 198.
Steckler, T., et al. 2005. Behav. Brain. Res. 164, 52.
Mabire, D., et al. 2005. J. Med. Chem. 48, 2134.
Fukunaga, I., et al. 2007. Br. J. Pharmacol. 151, 870.
Knopfel, T., et al. 2007. Br. J. Pharmacol. 151, 723.
Achat-Mendes, C., et al. 2012. J. Pharmacol. Exp. Ther. 343, 214.

Brochure

Titre
Pathways and Biomarkers of Glutamatergic Synapse Flyer
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-November-2017 JSW
Synonyms(3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
DescriptionAn extremely potent, non-competitive antagonist for mGlu receptor subtype 1 (Ki = 0.34 nM; IC50 = 0.55 nM). 400-fold more selective for mGlu1 than for mGlu5 and no interaction with mGlu2, mGlu3, mGlu4, mGlu6, AMPA or NMDA receptors (IC50 >10 µM). Centrally active following systemic administration. Widely used for studying substance abuse, learning and memory, and neural plasticity.
FormWhite to off-white solid
CAS number409345-29-5
Chemical formulaC₂₀H₂₃NO₃
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (25 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLavreysen, H., et al. 2004. Neuropharmacology. 47, 961.
Steckler, T., et al. 2005. Psychopharmacology. 179, 198.
Steckler, T., et al. 2005. Behav. Brain. Res. 164, 52.
Mabire, D., et al. 2005. J. Med. Chem. 48, 2134.
Fukunaga, I., et al. 2007. Br. J. Pharmacol. 151, 870.
Knopfel, T., et al. 2007. Br. J. Pharmacol. 151, 723.
Achat-Mendes, C., et al. 2012. J. Pharmacol. Exp. Ther. 343, 214.