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505983 NS1738 - CAS 501684-93-1 - Calbiochem

NS1738 - CAS 501684-93-1 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 1-(5-chloro-2-hydroxyphenyl)-3-(2-chloro-5-(trifluoromethyl)phenyl)urea, α7 nAChR positive allosteric modulator, NS1738, NS 1738, NS-1738

Primary Target: α7 AChR
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      501684-93-1C₁₄H₉Cl₂F₃N₂O₂
      Description
      OverviewA biarylurea derivative that acts as a selective positive allosteric modulator selective for α7 nicotinic acetylcholine receptors (α7 nAChR) without substantial activity for α4β2, α3β3 and α1-containing receptors. Exhibits cognitive enhancing effects in vivo.
      Catalogue Number505983
      Brand Family Calbiochem®
      Synonyms1-(5-chloro-2-hydroxyphenyl)-3-(2-chloro-5-(trifluoromethyl)phenyl)urea, α7 nAChR positive allosteric modulator, NS1738, NS 1738, NS-1738
      References
      ReferencesFreitas, K., et al., 2013. J. Pharmacol. Exp. Ther. 344, 264.
      Timmermann, B., J. et al., 2007, Pharmacol. Exp. Ther. 323, 294.
      Faghih, R., 2007. Recent Pat CNS Drug Discov. 2, 99.
      Product Information
      CAS number501684-93-1
      FormBeige powder
      Hill FormulaC₁₄H₉Cl₂F₃N₂O₂
      Chemical formulaC₁₄H₉Cl₂F₃N₂O₂
      Structure formula ImageStructure formula Image
      Quality SegmentMQ100
      Applications
      Biological Information
      Primary Targetα7 AChR
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Référence GTIN
      505983 0

      Documentation

      NS1738 - CAS 501684-93-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Freitas, K., et al., 2013. J. Pharmacol. Exp. Ther. 344, 264.
      Timmermann, B., J. et al., 2007, Pharmacol. Exp. Ther. 323, 294.
      Faghih, R., 2007. Recent Pat CNS Drug Discov. 2, 99.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-October-2013 JSW
      Synonyms1-(5-chloro-2-hydroxyphenyl)-3-(2-chloro-5-(trifluoromethyl)phenyl)urea, α7 nAChR positive allosteric modulator, NS1738, NS 1738, NS-1738
      DescriptionA biarylurea derivative that acts as a selective positive allosteric modulator selective for α7 nicotinic acetylcholine receptors (α7 nAChR) without substantial activity for α4β2, α3β3 and α1-containing receptors. Exhibits cognitive enhancing effects in vivo.
      FormBeige powder
      CAS number501684-93-1
      Chemical formulaC₁₄H₉Cl₂F₃N₂O₂
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFreitas, K., et al., 2013. J. Pharmacol. Exp. Ther. 344, 264.
      Timmermann, B., J. et al., 2007, Pharmacol. Exp. Ther. 323, 294.
      Faghih, R., 2007. Recent Pat CNS Drug Discov. 2, 99.