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504974 Philanthotoxin-7,4 - CAS 401601-12-5 - Calbiochem

Philanthotoxin-7,4 - CAS 401601-12-5 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (S)-N-(1-((7-((4-aminobutyl)amino)heptyl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)butyramide, Philanthotoxin-74, PhTx-74, AMPA Glutamate Antagonist, Philanthotoxin-7,4

Primary Target: AMPA
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      401601-12-5C₂₄H₄₂N₄O₃•2HCl
      Description
      Overview

      This product has been discontinued.



      A potent competitive antagonist highly selective for GluA1, GluA3, and GluA1/A2 subtype AMPA receptors (Ki = 0.168 and 1.6 µM for GluA1 and GluA1/A2, respectively). Negligible effect at GluA2 and GluA2/A3 subtype AMPA receptors. Used in studies of circadian rhythm, addition, and sleep.
      Catalogue Number504974
      Brand Family Calbiochem®
      Synonyms(S)-N-(1-((7-((4-aminobutyl)amino)heptyl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)butyramide, Philanthotoxin-74, PhTx-74, AMPA Glutamate Antagonist, Philanthotoxin-7,4
      References
      ReferencesJackson, C., et al. 2011. J. Neurosci. 31, 7511.
      Lante, F., et al. 2011. J. Neurosci. 31, 3953.
      Argilli, E., et al. 2008. J. Neurosci. 28, 9092.
      Nilsen, A., et al. 2007. J. Am. Chem. Soc. 129, 4902.
      Kromann, H. et al. 2002. J. Med. Chem. 45, 5745.
      Product Information
      CAS number401601-12-5
      FormLyophilized powder
      FormulationSupplied as a dihydrochloride salt.
      Hill FormulaC₂₄H₄₂N₄O₃•2HCl
      Chemical formulaC₂₄H₄₂N₄O₃•2HCl
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetAMPA
      Primary Target K<sub>i</sub>0.168 and 1.6 →M for GluA1 and GluA1/A2, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Référence GTIN
      504974 0

      Documentation

      Philanthotoxin-7,4 - CAS 401601-12-5 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Jackson, C., et al. 2011. J. Neurosci. 31, 7511.
      Lante, F., et al. 2011. J. Neurosci. 31, 3953.
      Argilli, E., et al. 2008. J. Neurosci. 28, 9092.
      Nilsen, A., et al. 2007. J. Am. Chem. Soc. 129, 4902.
      Kromann, H. et al. 2002. J. Med. Chem. 45, 5745.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2013 JSW
      Synonyms(S)-N-(1-((7-((4-aminobutyl)amino)heptyl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)butyramide, Philanthotoxin-74, PhTx-74, AMPA Glutamate Antagonist, Philanthotoxin-7,4
      DescriptionA potent competitive antagonist highly selective for GluA1, GluA3, and GluA1/A2 subtype AMPA receptors (Ki = 0.168 and 1.6 µM for GluA1 and GluA1/A2, respectively). Negligible effect at GluA2 and GluA2/A3 subtype AMPA receptors. Used in studies of circadian rhythm, addition, and sleep.
      FormLyophilized powder
      FormulationSupplied as a dihydrochloride salt.
      CAS number401601-12-5
      Chemical formulaC₂₄H₄₂N₄O₃•2HCl
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesJackson, C., et al. 2011. J. Neurosci. 31, 7511.
      Lante, F., et al. 2011. J. Neurosci. 31, 3953.
      Argilli, E., et al. 2008. J. Neurosci. 28, 9092.
      Nilsen, A., et al. 2007. J. Am. Chem. Soc. 129, 4902.
      Kromann, H. et al. 2002. J. Med. Chem. 45, 5745.