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565645 SCH-202676

A cell-permeable thiazole compound that reversibly inhibits both agonist and antagonist binding to GPCRs.

SCH-202676 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-(2,3-Diphenyl-1,2,4-thiadiazol-5-(2H)-ylidene)methanamine, HBr

Primary Target: Inhibits both agonist and antagonist binding to G protein-coupled receptors (GPCRs)
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      70375-43-8C₁₅H₁₃N₃S • HBr
      Description
      Overview

      This product has been discontinued.





      A cell-permeable thiazole compound that reversibly inhibits both agonist and antagonist binding to G protein-coupled receptors (GPCRs), including μ-, δ-, and κ-opioid, α- and β-adrenergic, muscarinic M1 and M2, and dopaminergic D1 and D2 receptors (IC50 values range from 0.1 to 1.8 μM). Has no direct effect on G protein activity.
      Catalogue Number565645
      Brand Family Calbiochem®
      SynonymsN-(2,3-Diphenyl-1,2,4-thiadiazol-5-(2H)-ylidene)methanamine, HBr
      References
      ReferencesFawzi, A.B., et al. 2001. Mol. Pharmacol. 59, 30.
      Product Information
      CAS number70375-43-8
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₅H₁₃N₃S • HBr
      Chemical formulaC₁₅H₁₃N₃S • HBr
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetInhibits both agonist and antagonist binding to G protein-coupled receptors (GPCRs)
      Primary Target IC<sub>50</sub>From 0.1 to 1.8 µM inhibiting both agonist and antagonist binding to G protein-coupled receptors (GPCRs), including µ-, δ-, and κ-opioid, α- and β-adrenergic, muscarinic M1 and M2, and dopaminergic D1 and D2 receptors
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Référence GTIN
      565645 0

      Documentation

      SCH-202676 FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      SCH-202676 Certificats d'analyse

      TitreNuméro de lot
      565645

      Références bibliographiques

      Aperçu de la référence bibliographique
      Fawzi, A.B., et al. 2001. Mol. Pharmacol. 59, 30.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-September-2008 RFH
      SynonymsN-(2,3-Diphenyl-1,2,4-thiadiazol-5-(2H)-ylidene)methanamine, HBr
      DescriptionA cell-permeable thiazole compound that reversibly inhibits both agonist and antagonist binding to G protein-coupled receptors (GPCRs), including µ-, δ-, and κ-opioid, α- and β-adrenergic, muscarinic M1 and M2, and dopaminergic D1 and D2 receptors (IC50 values range from 0.1 to 1.8 µM). Exhibits no direct effects on G protein activity.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number70375-43-8
      Chemical formulaC₁₅H₁₃N₃S • HBr
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesFawzi, A.B., et al. 2001. Mol. Pharmacol. 59, 30.