Viscosity Challenges in TFF

WEBINAR

Viscosity is one major challenge in manufacturing and formulating highly concentrated antibody drug products suitable for subcutaneous injection. Especially during concentration steps in downstream processing, attractive interactions and resulting high viscosity bear challenges that can limit the maximum protein concentration. The selection of suitable tangential flow filtration (TFF) cassettes, paired with the Viscosity Reduction Platform, consisting of viscosity-modifying excipient combinations that provide a tailored solution to address viscosity issues, enables significantly higher target protein concentrations with improved processing economics.

In this webinar, you will learn:

• Challenges arising from highly concentrated protein solutions during formulation by TFF
• The impact of TFF cassette design
• Benefits of viscosity-reducing excipient combination during TFF