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Merck

1.06323

SAFC

Sodium hydrogen carbonate

EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, JP, USP, FCC, E 500

Synonym(s):

Sodium bicarbonate

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About This Item

Linear Formula:
NaHCO3
CAS Number:
144-55-8
Molecular Weight:
84.01
Beilstein:
4153970
MDL number:
MFCD00003528
UNSPSC Code:
12352302
E Number:
E500
EC Index Number:
205-633-8

Key Documents

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Agency

BP
ChP
JP
Ph. Eur.
USP

Quality Level

500

reg. compliance

FCC

product line

EMPROVE® ESSENTIAL

form

solid

pH

8.6 (20 °C, 50 g/L in H2O)

pKa (25 °C)

(1) 6.37, (2) 10.25 (carbonic acid)

mp

270 °C (decomposition)

solubility

96 g/L

density

2.22 g/cm3 at 20 °C
2.16 g/mL at 25 °C (lit.)

application(s)

liquid formulation
ophthalmics
pharmaceutical
solid formulation

storage temp.

2-30°C

SMILES string

[Na+].OC([O-])=O

InChI

1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1

InChI key

UIIMBOGNXHQVGW-UHFFFAOYSA-M

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General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Sodium hydrogen carbonate is a commonly used ingredient in both food and pharmaceutics. In pharmaceutical applications, sodium hydrogen carbonate is used as pH adjuster, or a source of carbon dioxide in oral formulations such as effervescent tablets or granules.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

1063239052:
1063239027:
1063238890:
1063239321:
1063239103:
CO1I1063239029:
KR21063239029:
1063238889:
1063232500BWT:
1063239054:
1063235000:
CO1E1063232500:
1063234010:
1063239501:
1063238888:
1063239026:
1063239500:
1063239999:
1063230403:
1063239053:
1063239400:
CO1E1063239029:
1063239502:
1063234025:
1063230000:
1063231001:
1063239025:
1063233010:
1063239320:
1063239012:
1063232500:
MX11063239999:
1063239029BWT:
1.06323.9053:
US100632366:
CO1I1063239500:
1063239029:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
1.06323.250004022536074955
1.06323.902904022536995953
1.06323.950004022536995960