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Merck

85886

Streptomycin solution

~1 mg/mL in 1 mM EDTA, analytical standard

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About This Item

Empirical Formula (Hill Notation):
C21H39N7O12 · 1.5H2SO4
CAS Number:
3810-74-0
Molecular Weight:
728.69
NACRES:
NA.24
PubChem Substance ID:
329769423
UNSPSC Code:
41116107
MDL number:
MFCD00037023

Key Documents

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Product Name

Streptomycin solution, ~1 mg/mL in 1 mM EDTA, analytical standard

InChI

1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1

SMILES string

OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)C=O)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)C=O)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N

InChI key

QTENRWWVYAAPBI-YZTFXSNBSA-N

grade

analytical standard

form

liquid

concentration

~1 mg/mL in 1 mM EDTA

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

colorless

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

application(s)

pharmaceutical (small molecule)

format

single component solution

mode of action

protein synthesis | interferes

storage temp.

2-8°C

Quality Level

100

Related Categories

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.
Streptomycin solution has been used as a standard in the determination of streptomycin, present in honey using high performance liquid chromatography(HPLC).

Biochem/physiol Actions

Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.

Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.

Antimicrobial Spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.

General description

Chemical structure: aminoglycoside

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Packaging

10ml

Preparation Note

This product contains 1 mg/mL Streptomycin in 1 mM EDTA and should be stored at 2-8°C.

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK2265
BCCG2612
BCCB9360
BCBV5142

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Validation of a high performance liquid chromatography (HPLC) method to detect and quantify some antibiotics residues in honey
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Advances in Animal and Veterinary Sciences, 3, 295-301 (2015)
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