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EPS003

CUDC 101

A potent inhibitor of HDACs and receptor tyrosine kinases

Synonym(s):

7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide, Heptanamide, 7-[[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-hydroxy

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About This Item

Empirical Formula (Hill Notation):
C24H26N4O4
CAS Number:
1012054-59-9
Molecular Weight:
434.49
MDL number:
MFCD15528940
UNSPSC Code:
12352200
NACRES:
NA.41
Assay:
≥98% (HPLC)
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Quality Segment

100

assay

≥98% (HPLC)

color

white

solubility

DMSO: soluble

storage temp.

−20°C

SMILES string

N(O)C(=O)CCCCCCOc1cc2c(ncnc2Nc3cc(ccc3)C#C)cc1OC

InChI

1S/C24H26N4O4/c1-3-17-9-8-10-18(13-17)27-24-19-14-22(21(31-2)15-20(19)25-16-26-24)32-12-7-5-4-6-11-23(29)28-30/h1,8-10,13-16,30H,4-7,11-12H2,2H3,(H,28,29)(H,25,26,27)

InChI key

PLIVFNIUGLLCEK-UHFFFAOYSA-N

General description

A potent multitargeted inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC50 values of 4.4, 2.4, and 15.7 nM, respectively.

Displays potent antiproliferative and proapoptotic activities against cultured and implanted tumor cells that are sensitive or resistant to several approved single-targeted drugs.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EPS003-25MG: + EPS003-5MG:

jan

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