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M5820

M344

Name: M344
Brand: SIGMA

≥98% (HPLC), HDAC inhibitor, powder

Synonym(s):

4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide, MS 344, D237, N-Hydroxy-7-(4-dimethylaminobenzoyl)-aminoheptanamide

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₅N₃O₃

CAS Number:

251456-60-7

Molecular Weight:

307.39

UNSPSC Code:

12352200

PubChem Substance ID:

329818022

NACRES:

NA.77

MDL number:

MFCD03453554

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

protect from light

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Properties

Product Name

M344, ≥98% (HPLC), powder

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN(C)c1ccc(cc1)C(=O)NCCCCCCC(=O)NO

InChI

1S/C16H25N3O3/c1-19(2)14-10-8-13(9-11-14)16(21)17-12-6-4-3-5-7-15(20)18-22/h8-11,22H,3-7,12H2,1-2H3,(H,17,21)(H,18,20)

InChI key

MXWDSZWTBOCWBK-UHFFFAOYSA-N

Description

Biochem/physiol Actions

M344 is a HDAC inhibitor and subtype selective for HDAC6 over HDAC1.

M344 is a HDAC inhibitor; subtype selective for HDAC6 over HDAC1. M344 inhibits HDAC (IC₅₀ = 100 nM) and also inhibits hyperacetylation of histone H4, terminal cell differentiation, transcription (γ-globin), and tumor cell death.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

M5820-5MG: + M5820-1MG: + M5820-BULK: + M5820-VAR:

jan

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Certificates of Analysis (COA)

Lot/Batch Number

098K4709

116K4714

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