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A4544

L-Ascorbic acid

Name: <SC>L</SC>-Ascorbic acid
Brand: SIGMA

suitable for cell culture, suitable for plant cell culture, ≥98%

Synonym(s):

L-Threoascorbic acid, Antiscorbutic factor, Vitamin C

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About This Item

Empirical Formula (Hill Notation):

C₆H₈O₆

CAS Number:

50-81-7

Molecular Weight:

176.12

UNSPSC Code:

12352201

NACRES:

NA.21

PubChem Substance ID:

24890875

EC Number:

200-066-2

Beilstein/REAXYS Number:

84272

MDL number:

MFCD00064328

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Properties

Quality Level

200

assay

≥98%

form

powder

mol wt

M_w 176.12 g/mol

technique(s)

cell culture | mammalian: suitable, cell culture | plant: suitable

color

white to light yellow

pH

1.0-2.5 (25 °C, 176 g/L in water)

mp

190-194 °C (dec.)

solubility

water: soluble 50 mg/mL

SMILES string

OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O

InChI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

InChI key

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

Gene Information

human ... SLC23A2(9962)

Description

General description

L-ascorbic acid also called vitamin C, is a water soluble vitamin and acts as a reducing agent for various biochemical reactions. Ascorbic acid plays a key role in the production of collagen. Ascorbic acid is essential for neurodevelopment, neurotransmitter synthesis and modulates neuronal synapsis. Dietary inadequacy of vitamin C has negative impact on cognition.

Application

L-ascorbic acid has been used as an ingredient in the basal medium for bovine mammary epithelial cells and oocyte-granulosa cell complexes. It has been used as a supplement in the osteogenic medium for osteogenic differentiation.

Biochem/physiol Actions

Ascorbic Acid, also known as Vitamin C, is a six-carbon lactone produced by plants and some animal species but not by humans and other primates. Ascorbic acid functions as an enzymatic cofactor for multiple enzymes, serving as an electron donor for monooxygenases and dioxygenases. Ascorbic acid also functions as a powerful antioxidant, particularly in regards to reactive oxygen species.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

Ascorbate in Cell Culture

Importance and uses of ascorbate in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures

Multipotency and cardiomyogenic potential of human adipose-derived stem cells from epicardium, pericardium, and omentum

Wystrychowski W, et al.

Stem Cell Research & Therapy, 7(1), 84-84 (2016)

The effect of mesenchymal stromal cells on the osseoinduction of impaction grafts

Korda M, et al.

Tissue Engineering: Part A, 16(2), 675-683 (2009)

Mitochondrial dysfunction of in vitro grown rabbit oocytes results in preimplantation embryo arrest after activation

Kanaya H, et al.

Journal of Reproduction and Development, 53(3), 631-637 (2007)

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