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Merck

C1879

Choline chloride

synthetic, ≥98%, Choline acetyltransferase substrate, powder or crystals

Synonym(s):

(2-Hydroxyethyl)trimethylammonium chloride

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About This Item

Linear Formula:
(CH3)3N(Cl)CH2CH2OH
CAS Number:
67-48-1
Molecular Weight:
139.62
NACRES:
NA.77
PubChem Substance ID:
57653990
UNSPSC Code:
12352200
EC Number:
200-655-4
MDL number:
MFCD00011721
Beilstein/REAXYS Number:
3563126
Assay:
≥98%
Form:
powder or crystals
Quality level:
200

Key Documents

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Product Name

Choline chloride, ≥98%

InChI key

SGMZJAMFUVOLNK-UHFFFAOYSA-M

InChI

1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1

SMILES string

[Cl-].C[N+](C)(C)CCO

biological source

synthetic

assay

≥98%

form

powder or crystals

technique(s)

cell culture | mammalian: suitable

color

colorless to white

mp

302-305 °C (dec.) (lit.)

Quality Level

200

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Application

Choline chloride has been used:
  • as a substrate for measuring choline oxidase enzyme activity using fluorescence measurements
  • as a component of non-physiological buffers for testing calcium based inhibition of cytochrome c oxidaseP
  • as a component of perfusate solution for studying arterial pressure in jejunum samples

Biochem/physiol Actions

Choline chloride treatment of radish seeds modulates phosphatidylcholine and phosphatidylethanolamine levels. It elicits hepatoprotective effects and modulates methyl carbon based metabolic pathways.

General description

Choline acetyltransferase substrate
Choline chloride is the synthetic form of vitamin B4, choline and is a common poultry feed.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

C1879-VAR: + C1879-BULK: + C1879-500G: + C1879-1KG: + C1879-5KG: + C1879-100G: + C1879-25G:

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Certificates of Analysis (COA)

Lot/Batch Number
WXBD6900V
WXBD6899V
WXBD6378V
WXBD5967V
WXBD5544V

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An investigation into the relationship between small intestinal fluid secretion and systemic arterial blood pressure in the anesthetized rat
Lucas ML and Morrison JD
Physiological Reports, 3(5) (2015)
Evaluation of polyherbal formulation and synthetic choline chloride on choline deficiency model in broilers: implications on zootechnical parameters, serum biochemistry and liver histopathology
Selvam R, et al.
Asian-Australasian Journal of Animal Sciences, 31(11), 1795-1795 (2018)
Effect of choline chloride on the lipid content and composition in the leaves of principal magnetically-oriented radish types
Novitskaya GV, et al.
Russian Journal of Plant Physiology, 51(3), 361-371 (2004)
Choline and methionine differentially alter methyl carbon metabolism in bovine neonatal hepatocytes
Chandler TL and White HM
PLoS ONE, 12(2), e0171080-e0171080 (2017)
Rapid enzymatic method for the determination of phosphoryl choline using the fluorescence of the enzyme choline oxidase. Sequential determination of choline and phosphorylcholine in milk powder for children
Sanz-Vicente I, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 123, 259-266 (2015)
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