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Merck

P0778

Pindolol

≥98% (TLC), β1-adrenoceptor antagonist, powder

Synonym(s):

1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol, 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol

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About This Item

Empirical Formula (Hill Notation):
C14H20N2O2
CAS Number:
13523-86-9
Molecular Weight:
248.32
NACRES:
NA.77
PubChem Substance ID:
24277795
UNSPSC Code:
12352200
EC Number:
236-867-9
MDL number:
MFCD00010530
Assay:
≥98% (TLC)
Form:
powder
Quality level:
200

Key Documents

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Product Name

Pindolol, ≥98% (TLC), powder

InChI key

JZQKKSLKJUAGIC-UHFFFAOYSA-N

InChI

1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3

SMILES string

CC(C)NCC(O)COc1cccc2[nH]ccc12

assay

≥98% (TLC)

form

powder

color

white to off-white

mp

167-171 °C (lit.)

solubility

0.1 M NaOH: 0.2 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL, 0.1 M HCl: 20 mg/mL, acetic acid: 50 mg/mL, H2O: insoluble

originator

Novartis

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... ADRB1(153), ADRB2(154), HTR1A(3350)

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Application

Pindolol has been used in intestinal transport and metabolism assays and cassette mix preparation.

Biochem/physiol Actions

β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator. Pindolol is a non-cardioselective beta-adrenergic blocking agent. It possesses intrinsic sympathomimetic activity.
β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Shelf-life of the powder is at least five years.
This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

P0778-VAR: + P0778-1G: + P0778-250MG: + P0778-BULK: + P0778-5G:

jan

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Certificates of Analysis (COA)

Lot/Batch Number
SLCL5990
SLCJ7404
SLCF7364
SLCD6382
SLBT6280

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Pindolol: a review of its pharmacology, pharmacokinetics, clinical uses, and adverse effects
Golightly L K
Pharmacotherapy, 2(3), 134-147 (1982)
Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts
Pelkonen L, et al.
European Journal of Pharmaceutical Sciences, 162-168 (2017)
The biotransformation of prasugrel, a new thienopyridine prodrug, by the human carboxylesterases 1 and 2
Williams E T, et al.
Drug Metabolism and Disposition (2008)
C M Hysek et al.
Emergency medicine journal : EMJ, 27(8), 586-589 (2010-04-10)
MDMA (3,4-methylenedioxymethamphetamine, 'Ecstasy') produces tachycardia and hypertension and is rarely associated with cardiovascular and cerebrovascular complications. In clinical practice, beta-blockers are often withheld in patients with stimulant intoxication because they may increase hypertension and coronary artery vasospasm due to loss
Maria J Portella et al.
The Journal of clinical psychiatry, 72(7), 962-969 (2010-11-03)
Since depression entails not only dramatic personal disruption but also a huge amount of medical and socioeconomic burden, slowness of antidepressant action and difficulties to attain remission are entangled issues to be solved. Given the controversial previous findings with enhancing
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