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Merck

T0632

Sodium thioglycolate

≥96.5% (iodometric)

Synonym(s):

Mercaptoacetic acid sodium salt, Thioglycolic acid sodium salt

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About This Item

Linear Formula:
HSCH2COONa
CAS Number:
367-51-1
Molecular Weight:
114.10
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
24899901
EC Number:
206-696-4
Beilstein/REAXYS Number:
4569109
MDL number:
MFCD00043386

Key Documents

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InChI key

GNBVPFITFYNRCN-UHFFFAOYSA-M

InChI

1S/C2H4O2S.Na/c3-2(4)1-5;/h5H,1H2,(H,3,4);/q;+1/p-1

SMILES string

[Na+].[O-]C(=O)CS

assay

≥96.5% (iodometric)

form

powder

color

white to off-white

useful pH range

6.7 (20 °C, 100 g/L)

mp

>300 °C (lit.)

solubility

water: ~609.1 g/L at 20 °C (OECD Test Guideline 105)

storage temp.

−20°C

Quality Level

200

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Application

Sodium thioglycolate has been used:
  • as a growth supplement in enrichment media and to study its effect on Arcobacter
  • in influenza hemagglutinin formulation in order to reduce disulfide-mediated cross-linking and early potency loss
  • in electron microscopy

Biochem/physiol Actions

Sodium thioglycolate acts as reducing agent and is suitable for anaerobic and microaerophilic bacterial growth.
Sodium thioglycolate is a commonly used reagent for bacteriological research to maintain reducing conditions in media. Thioglycolate can also protect enzymes against inactivation by maintaining protein thiol groups in the reduced state. Thioglycolate medium is frequently used in inflammation research to elicit a neutrophil and macrophage response in vivo.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Disclaimer

At room temperature, concentrations over 70% in water tend to form 1-2% thioglycolides per month which hydrolyze to the original free compound when made acidic or alkaline. The 70% solution oxidizes in air but is stable at room temperature when tightly closed. Thioglycolate salts may also lose purity on storage. The exclusion of air does not materially improve stability.

pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Aquatic Chronic 3 - Met. Corr. 1 - Skin Sens. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

T0632-25G: + T0632-100G: + T0632-VAR: + T0632-BULK: + T0632-500G:

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Certificates of Analysis (COA)

Lot/Batch Number
STBK8327
STBK8332
STBK8331
STBK8328
STBK8329

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Improved stability of recombinant hemagglutinin using a formulation containing sodium thioglycolate
Rhodes DG, et al.
Vaccine, 33(44), 6011-6016 (2015)
Romina A Cutrullis et al.
Immunobiology, 222(2), 423-431 (2016-09-04)
The proinflammatory cytokine macrophage migration inhibitory factor (MIF) is a key player in innate immunity. MIF has been considered critical for controlling acute infection by the protozoan Trypanosoma cruzi, but the underlying mechanisms are poorly understood. Our study aimed to
Kim De Paepe et al.
PeerJ, 7, e6293-e6293 (2019-02-01)
Undigestible, insoluble food particles, such as wheat bran, are important dietary constituents that serve as a fermentation substrate for the human gut microbiota. The first step in wheat bran fermentation involves the poorly studied solubilization of fibers from the complex
Development of Parvalbumin-Expressing Basket Terminals in Layer II of the Rat Medial Entorhinal Cortex
Berggaard N, et al.
eNeuro, 5(3) (2018)
Clinical Ophthalmology: Contemporary Perspectives - E-Book, 176-176 (2012)
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