218759
Caspase-8 Inhibitor II
≥98% (HPLC), powder, Caspase-8 inhibitor, Calbiochem®
別名:
Caspase-8 Inhibitor II, Z-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III
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この商品について
実験式（ヒル表記法）:
C30H43FN4O11
分子量:
654.68
UNSPSC Code:
12352200
NACRES:
NA.77
製品名
Caspase-8 Inhibitor II, The Caspase-8 Inhibitor II controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
color
white to yellow
solubility
DMSO: 10 mM
shipped in
ambient
storage temp.
−20°C
Quality Level
Analysis Note
≥98% (HPLC)
Biochem/physiol Actions
Cell permeable: yes
Primary Target
caspase-8
caspase-8
Product does not compete with ATP.
Reversible: no
Disclaimer
Toxicity: Standard Handling (A)
Other Notes
Takizawa, T., et al. 1999. Microbiol. Immunol.43, 245.
Martin, D.A., et al. 1998. J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998. FEBS Lett.425, 61.
Thornberry, N.A., and Lazebnik, Y. 1998. Science281, 1312.
Martin, D.A., et al. 1998. J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998. FEBS Lett.425, 61.
Thornberry, N.A., and Lazebnik, Y. 1998. Science281, 1312.
Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 8 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
General description
A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218840 ) in DMSO is also available.
保管分類
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Zahara L Chaudhry et al.
Brain sciences, 12(4) (2022-04-22)
The outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) signifies a serious worldwide concern to public health. Both transcriptome and proteome of SARS-CoV-2-infected cells synergize the progression of infection in host, which may exacerbate symptoms and/or
Gurdeep Marwarha et al.
Biomedicines, 10(1) (2022-01-22)
Apoptotic cell death of cardiomyocytes is a characteristic hallmark of ischemia-reperfusion (I/R) injury. The master hypoxamiR, microRNA-210 (miR-210), is considered the primary driver of the cellular response to hypoxic stress. However, to date, no consensus has emerged with regards to
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| 218759-1MGCN | 04055977218619 |
| 218759-250UGCN | 04055977218626 |
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